Fonkalsrud E W
Ann Surg. 1985 Aug;202(2):145-52. doi: 10.1097/00000658-198508000-00002.
Seventy-eight patients with ulcerative colitis refractory to medical therapy and eight with colonic polypisis have undergone total colectomy mucosal proctectomy, endorectal ileal pull-through with ileoanal anastomosis, and diverting ileostomy at the UCLA Medical Center during the past 7 years. Seventy-seven patients underwent a second stage operation with construction of a lateral isoperistaltic ileal reservoir, 12 to 30 cm long, and closure of the ileostomy. A reservoir 10 to 15 cm long appears optimal for children, and one 20 cm long appears to function best for adults. Major complications were either related to obstruction of the reservoir outlet from leaving a rectal muscle cuff longer than 6 cm, and/or constructing the reservoir too long in the early experience (16 patients), or from cuff abscesses (four patients). Out of the 77 patients, these problems led to reservoir removal in three, temporary ileostomy in eight, and reservoir revision in 16. Persistent cuff abscess was the cause for reservoir removal in two of four patients. Continence was achieved in all patients within 2 weeks. Good to excellent results were obtained in 65 patients. At one year, 78% were completely continent during the day, 18% had minor seepage, and four per cent had occasional soiling. Frequency of defecation in patients without complications, or those surgically corrected, was seven per 24 hours within 3 months. There were no deaths. Six patients were found to have unsuspected cancer at operation. No patient experienced bladder dysfunction or abnormal sexual function. Although a technically difficult operation, the long-term results indicate that the pullthrough operation is a good alternative to proctocolectomy with ileostomy.
在过去7年中,78例药物治疗无效的溃疡性结肠炎患者和8例结肠息肉病患者在加州大学洛杉矶分校医疗中心接受了全结肠切除黏膜直肠切除术、经直肠回肠拖出术并进行回肠肛管吻合术,以及转流性回肠造口术。77例患者接受了二期手术,构建了一个长12至30厘米的侧方蠕动性回肠贮袋,并关闭了回肠造口。对于儿童,一个长10至15厘米的贮袋似乎是最佳选择,而对于成年人,一个长20厘米的贮袋似乎功能最佳。主要并发症要么与因保留直肠肌袖超过6厘米导致贮袋出口梗阻有关,和/或在早期经验中(16例患者)贮袋构建过长,要么与肌袖脓肿(4例患者)有关。在这77例患者中,这些问题导致3例患者切除贮袋,8例患者临时行回肠造口术,16例患者对贮袋进行修复。持续性肌袖脓肿是4例患者中2例切除贮袋的原因。所有患者在2周内均实现了控便。65例患者获得了良好至极佳的效果。一年时,78%的患者白天完全能自控,18%有少量渗漏,4%偶尔有粪便污染。无并发症或手术矫正后的患者排便频率在3个月内为每24小时7次。无死亡病例。6例患者在手术时发现有未被怀疑的癌症。没有患者出现膀胱功能障碍或性功能异常。尽管该手术技术难度较大,但长期结果表明,拖出术是全结肠切除回肠造口术的一个良好替代方案。