Legha S S, Haq M, Rabinowits M, Lawson M, McCredie K
Arch Intern Med. 1985 Jul;145(7):1208-11.
We evaluated the efficacy and the complications of 65 silicone elastomer catheters inserted percutaneously for long-term venous access for administration of chemotherapy, antibiotics, and blood products in patients with metastatic cancer. Treatments were administered either in the hospital or in the outpatient clinic, using a portable infusion pump. The median indwelling time of catheters was 238 days (range, two to 521). The projected duration of catheter function, when the electively removed catheters were censured, was 310 days. Twenty-three catheters were removed because of malfunction, while the remaining either were discontinued electively (20) or were functioning at the conclusion of the study (22). The problems necessitating removal of 23 catheters were inadvertent dislodgement from loose sutures (eight), mechanical damage to the catheters (four), sepsis (four), phlebitis (four), intraluminal blockage with a clot (two), and cellulitis (one). We conclude that silicone elastomer catheters are safe and reliable for extended venous access for cancer chemotherapy. They are easy to insert and remove and can be replaced with a guide wire without requiring surgical intervention.
我们评估了65根经皮插入的硅橡胶导管的疗效和并发症，这些导管用于为转移性癌症患者建立长期静脉通路，以便输注化疗药物、抗生素和血液制品。治疗在医院或门诊进行，使用便携式输液泵。导管的中位留置时间为238天（范围为2至521天）。当对选择性拔除的导管进行审查时，导管功能的预计持续时间为310天。23根导管因故障被拔除，其余的要么被选择性停用（20根），要么在研究结束时仍在发挥作用（22根）。导致23根导管被拔除的问题包括因缝线松动导致意外移位（8根）、导管机械损伤（4根）、败血症（4根）、静脉炎（4根）、管腔内血栓阻塞（2根）和蜂窝织炎（1根）。我们得出结论，硅橡胶导管对于癌症化疗的长期静脉通路是安全可靠的。它们易于插入和拔除，并且可以在无需手术干预的情况下通过导丝进行更换。
