Li Junyong, Li Jian, Chen Fei, Gao Yi
Department of Urology, Renmin Hospital, Hubei University of Medicine, No. 39 Chaoyang Middle Road, Maojian District, Hubei, 442000, Shiyan, China.
Hormones (Athens). 2025 Mar 28. doi: 10.1007/s42000-025-00642-6.
This study aimed to investigate the relationship between ACE2 expression in peripheral blood and the prognosis of patients with adrenal adenoma and hypertension.
We recruited 80 patients with adrenal adenoma and hypertension (47 males, 33 females) treated between March 2021 and September 2022. Patients were divided into high ACE2 expression (n = 26) and low ACE2 expression (n = 54) groups. General patient data, blood pressure, serum potassium, creatinine, and hormone levels (cortisol, aldosterone, catecholamines) were compared. The frequency of hypertensive episodes with palpitations was recorded. Correlations between ACE2 expression and prognosis were analyzed using Pearson correlation and Cox regression models.
The ACE2 high expression group had significantly lower blood pressure, serum creatinine, and hormone levels (P < 0.001), but higher serum potassium (P < 0.001) compared to the low expression group. Over 3 months, the incidence of hypertensive episodes with palpitations was lower in the high expression group (7.69%) compared to the low expression group (24.07%) (P = 0.002). The frequency of episodes was also lower in the high expression group (P = 0.016). Pearson correlation analysis showed a negative correlation between ACE2 expression and poor prognosis (P < 0.001). Multivariate Cox regression confirmed low ACE2 expression as an independent risk factor for poor prognosis (P < 0.001).
High ACE2 expression is associated with improved cardiovascular and renal function and lower incidence of hypertensive episodes in patients with adrenal adenoma and hypertension, suggesting a protective role of ACE2 in mitigating hypertension-related complications.
Not applicable.
本研究旨在探讨外周血中血管紧张素转换酶2（ACE2）表达与肾上腺腺瘤合并高血压患者预后之间的关系。
我们招募了2021年3月至2022年9月期间接受治疗的80例肾上腺腺瘤合并高血压患者（47例男性，33例女性）。患者被分为ACE2高表达组（n = 26）和低表达组（n = 54）。比较患者的一般资料、血压、血钾、肌酐及激素水平（皮质醇、醛固酮、儿茶酚胺）。记录伴有心悸的高血压发作频率。采用Pearson相关性分析和Cox回归模型分析ACE2表达与预后的相关性。
与低表达组相比，ACE2高表达组的血压、血清肌酐和激素水平显著更低（P < 0.001），但血钾更高（P < 0.001）。在3个月的时间里，高表达组伴有心悸的高血压发作发生率（7.69%）低于低表达组（24.07%）（P = 0.002）。高表达组的发作频率也更低（P = 0.016）。Pearson相关性分析显示ACE2表达与不良预后呈负相关（P < 0.001）。多因素Cox回归分析证实低ACE2表达是不良预后的独立危险因素（P < 0.001）。
ACE2高表达与肾上腺腺瘤合并高血压患者心血管和肾功能改善及高血压发作发生率降低相关，提示ACE2在减轻高血压相关并发症方面具有保护作用。
不适用。
