Honjin R, Yamashita T, Higashimoto M, Yamamoto M
Arch Histol Jpn. 1985 Feb;48(1):45-52. doi: 10.1679/aohc.48.45.
Radial components of the optic nerve of the mouse were studied by using thin sections and freeze-fracture replicas. The investigations were performed on normal optic nerves, as well as on those undergoing Wallerian degeneration following eyeball enucleation. Normal radial components in thin sections were observed as a series of light lines composed of small electron-lucent dots situated in the interperiod lines across the myelin sheath. They are frequently found in those parts of the myelin sheath lying near the outer and inner processes of the oligodendroglia. Radial components in freeze-fracture replica were observed as a parallel array of many ridges composed of a row of particles. The particles of radial components located in the deeper part of the myelin sheath lose their linear arrangement and fall into disorder in a relatively early post-operative period. The parallel array of rows of particles located closely beneath the outer processes of the oligodendroglia remained intact for a long period, even in a markedly distorted myelin sheath. The present observations suggest that the radial components are resistant against the disintegration of the myelin lamellae during Wallerian degeneration.
利用薄切片和冷冻断裂复制品对小鼠视神经的径向成分进行了研究。研究对象包括正常视神经以及眼球摘除后发生华勒氏变性的视神经。薄切片中的正常径向成分表现为一系列光线，由位于髓鞘跨周期线中的小电子透明点组成。它们经常出现在靠近少突胶质细胞外突和内突的髓鞘部分。冷冻断裂复制品中的径向成分表现为许多由一排颗粒组成的平行排列的脊。位于髓鞘较深部分的径向成分颗粒在术后相对早期就失去了线性排列并变得紊乱。即使在明显扭曲的髓鞘中，紧密位于少突胶质细胞外突下方的颗粒排的平行排列也能长期保持完整。目前的观察结果表明，在华勒氏变性过程中，径向成分对髓鞘板层的解体具有抗性。
