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痛敏肽系统对暴饮暴食样酒精消费的隔区-下丘脑调节。

Septo-hypothalamic regulation of binge-like alcohol consumption by the nociceptin system.

作者信息

Haun Harold, Hernandez Raul, Yan Luzi, Flanigan Meghan, Hon Olivia, Lee Sophia, Méndez Hernán, Roland Alison, Taxier Lisa, Kash Thomas

机构信息

Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.

Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA; Morgan Community College, Fort Morgan, CO 80701, USA.

出版信息

Cell Rep. 2025 Apr 22;44(4):115482. doi: 10.1016/j.celrep.2025.115482. Epub 2025 Mar 27.

DOI:10.1016/j.celrep.2025.115482
PMID:40153436
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12181985/
Abstract

High-intensity alcohol drinking during binge episodes contributes to the socioeconomic burden created by alcohol use disorders (AUDs), and nociceptin receptor (NOP) antagonists have emerged as a promising intervention. To better understand the contribution of the NOP system to binge drinking, we found that nociceptin-containing neurons of the lateral septum (LS) displayed increased excitability during withdrawal from binge-like alcohol drinking. LS activation promoted active avoidance and potentiated binge-like drinking behavior, whereas silencing of this population reduced alcohol drinking. LS form robust monosynaptic inputs locally within the LS and genetic deletion of NOP or microinjection of a NOP antagonist into the LS decreased alcohol intake. LS also project to the lateral hypothalamus and supramammillary nucleus of the hypothalamus, and genetic deletion of NOP from each site reduced alcohol drinking. Together, these findings implicate the septo-hypothalamic nociceptin system in excessive alcohol consumption and support NOP antagonist development for the treatment of AUD.

摘要

暴饮期间的高强度饮酒会加重酒精使用障碍（AUD）造成的社会经济负担，而孤啡肽受体（NOP）拮抗剂已成为一种有前景的干预措施。为了更好地理解NOP系统对暴饮的作用，我们发现，在从类似暴饮的酒精饮用中戒断期间，外侧隔区（LS）中含孤啡肽的神经元兴奋性增加。激活LS会促进主动回避并增强类似暴饮的饮酒行为，而沉默这群神经元则会减少酒精摄入。LS在LS内局部形成强大的单突触输入，NOP基因缺失或向LS中微量注射NOP拮抗剂会减少酒精摄入量。LS还投射到下丘脑外侧和下丘脑乳头体上核，从每个部位删除NOP基因都会减少酒精摄入。总之，这些发现表明隔区-下丘脑孤啡肽系统与过量饮酒有关，并支持开发NOP拮抗剂来治疗AUD。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/743f/12181985/fa916f90fd15/nihms-2076715-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/743f/12181985/9508ed929676/nihms-2076715-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/743f/12181985/38863b6a8faa/nihms-2076715-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/743f/12181985/5b33be765820/nihms-2076715-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/743f/12181985/915cbdf4d87a/nihms-2076715-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/743f/12181985/d051a40b110f/nihms-2076715-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/743f/12181985/bda5de7e83f4/nihms-2076715-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/743f/12181985/fa916f90fd15/nihms-2076715-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/743f/12181985/9508ed929676/nihms-2076715-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/743f/12181985/38863b6a8faa/nihms-2076715-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/743f/12181985/5b33be765820/nihms-2076715-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/743f/12181985/915cbdf4d87a/nihms-2076715-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/743f/12181985/d051a40b110f/nihms-2076715-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/743f/12181985/bda5de7e83f4/nihms-2076715-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/743f/12181985/fa916f90fd15/nihms-2076715-f0008.jpg

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4
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6
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