Chai Minghan, Jin Qiuli, Zhang Jie, Zhao Ying, Xue Qing
Department of Gynecology, Shanxian Central Hospital, Heze, Shandong, China.
Medicine (Baltimore). 2025 Mar 28;104(13):e42058. doi: 10.1097/MD.0000000000042058.
Adult granulosa cell tumors (AGCTs), representing the most prevalent subtype of sex cord-stromal tumors in the ovary, predominantly manifest in perimenopausal and postmenopausal women. A notably uncommon clinical manifestation of AGCTs is the concomitant development of pleural effusion, a condition that may be erroneously attributed to more prevalent etiologies such as cardiac insufficiency, pulmonary infections, or other malignant processes. Consequently, the occurrence of pleural effusion in association with AGCTs is atypical and warrants heightened clinical vigilance for such rare presentations. This article presents a detailed case report, aiming to enhance the timely identification and management of this condition, thereby optimizing patient prognosis.
A 60-year-old postmenopausal woman presented with a 1-month history of persistent chest tightness and dyspnea. Initial chest radiography demonstrated a right-sided pleural effusion. Thoracentesis was performed, providing transient symptomatic relief; however, the effusion persisted without complete resolution. Further diagnostic evaluation with computed tomography imaging revealed the presence of a pelvic mass, which necessitated surgical intervention for definitive management.
Histopathological analysis of the surgical specimen confirmed the diagnosis of an adult granulosa cell tumor originating from the left ovary.
Postoperative evaluation demonstrated a marked reduction in pleural effusion, with complete resolution achieved during the recovery period.
Throughout the follow-up surveillance, no evidence of tumor recurrence has been detected.
This case highlights the pivotal role of multidisciplinary collaboration in addressing complex clinical scenarios. Furthermore, it emphasizes the imperative for early detection and prompt intervention in cases of pelvic masses among postmenopausal women, underscoring the potential for improved clinical outcomes through timely and coordinated management.
成人颗粒细胞瘤（AGCTs）是卵巢性索间质肿瘤中最常见的亚型，主要发生于围绝经期和绝经后女性。AGCTs一种明显不常见的临床表现是并发胸腔积液，这种情况可能被错误地归因于更常见的病因，如心脏功能不全、肺部感染或其他恶性病变。因此，AGCTs合并胸腔积液的情况不典型，需要临床对此类罕见表现提高警惕。本文详细报告了一例病例，旨在加强对此病的及时识别和管理，从而优化患者预后。
一名60岁绝经后女性，有1个月持续胸闷和呼吸困难病史。最初的胸部X线检查显示右侧胸腔积液。进行了胸腔穿刺术，症状暂时缓解；然而，积液持续存在，未完全消退。计算机断层扫描成像的进一步诊断评估显示盆腔有肿块，需要手术干预以明确治疗。
手术标本的组织病理学分析证实为起源于左卵巢的成人颗粒细胞瘤。
术后评估显示胸腔积液明显减少，恢复期积液完全消退。
在整个随访监测期间，未发现肿瘤复发迹象。
该病例突出了多学科协作在处理复杂临床情况中的关键作用。此外，它强调了绝经后女性盆腔肿块早期检测和及时干预的必要性，强调了通过及时和协调的管理改善临床结果的潜力。
