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药物、行为和手术联合治疗重度肥胖合并多器官功能衰竭:一例报告。

A combination of drug, behavioral and surgical therapy to relieve from severe obesity complicated with multiple organs failure: A case report.

作者信息

Feng Feng, Zhang Jiaqi, Gao Yuqi, Ye Qiaoni, Wang Guiqi, Gu Jingfeng, Peng Liping

机构信息

Ministry of Education Key Laboratory of Molecular and Cellular Biology, Hebei Collaborative Innovation Center for Eco-Environment, College of Life Sciences, Hebei Normal University, Shijiazhuang, Hebei, China.

Department of Gastrointestinal Surgery, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.

出版信息

Medicine (Baltimore). 2025 Mar 28;104(13):e41846. doi: 10.1097/MD.0000000000041846.

DOI:10.1097/MD.0000000000041846
PMID:40153754
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11957622/
Abstract

RATIONALE

The prevalence of obesity and its associated complications is on the rise globally. Bariatric surgery has proven to be a very effective method to induce sustained weight loss as well as reduce obesity-related diseases, such as type 2 diabetes, hypertension and hyperlipemia.

PATIENT CONCERNS

The 30-year-old female patient, with BMI at 79.2 kg/m2 and abdominal circumference at 199 cm, gained weight continually, felt chest tightness and shortness of breath for 10 days.

DIAGNOSES

The patient was diagnosed with severe obesity complicated with multiple organs failure.

INTERVENTIONS

The patient was given a personal diet plan to lose weight. Besides, she was given noninvasive ventilator to improve ventilation dysfunction during night sleep, and hypoglycemic therapy and treatment of pulmonary hypertension were given to improve heart failure. When the weight was effectively reduced, bariatric surgery was performed to reduce weight more remarkable.

OUTCOMES

One month after surgery, the overall weight of the patient was significantly reduced with meliorative BMI at 58.6, and the blood glucose was significantly reduced to the normal level and her overall physique was thin down and slimmer than before.

LESSONS

Multi-disciplinary combination and comprehensive treatment can effectively reduce the risk of surgery. Moreover, surgery should not be performed as soon as possible for patients with extremely severe obesity, and preoperative weight loss can improve the organs function of patients.

摘要

理论依据

全球肥胖症及其相关并发症的患病率正在上升。减肥手术已被证明是一种非常有效的方法,可导致持续体重减轻,并减少与肥胖相关的疾病,如2型糖尿病、高血压和高脂血症。

患者关注点

这位30岁的女性患者,体重指数(BMI)为79.2kg/m²,腹围为199cm,体重持续增加,10天来感到胸闷和呼吸急促。

诊断

患者被诊断为重度肥胖合并多器官功能衰竭。

干预措施

为患者制定了个人减肥饮食计划。此外,给她使用无创呼吸机以改善夜间睡眠期间的通气功能障碍,并给予降糖治疗和肺动脉高压治疗以改善心力衰竭。当体重有效减轻后,进行减肥手术以更显著地减轻体重。

结果

术后一个月,患者总体重显著减轻,BMI改善至58.6,血糖显著降至正常水平,整体体型变瘦,比以前更苗条。

经验教训

多学科联合和综合治疗可有效降低手术风险。此外,对于极度肥胖的患者,不应尽早进行手术,术前减肥可改善患者的器官功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1d4/11957622/d7bb2da51cf5/medi-104-e41846-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1d4/11957622/d7bb2da51cf5/medi-104-e41846-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1d4/11957622/d7bb2da51cf5/medi-104-e41846-g001.jpg

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