Gravesteijn A S, van der Kruit A, Bet M, Beckerman H, Schoonheim M M, Heuvel O A van den, Vriend C, van Wegen E E H, de Jong B A, de Groot V, Hulst H E
Amsterdam UMC location Vrije Universiteit Amsterdam, Rehabilitation Medicine, De Boelelaan 1117, Amsterdam, the Netherlands; Amsterdam Neuroscience, Neuroinfection & -inflammation, Amsterdam, the Netherlands; Amsterdam Movement Sciences, Rehabilitation & Development, Amsterdam, the Netherlands; MS Center Amsterdam, Amsterdam, the Netherlands.
Amsterdam Neuroscience, Neuroinfection & -inflammation, Amsterdam, the Netherlands; MS Center Amsterdam, Amsterdam, the Netherlands; Amsterdam UMC location Vrije Universiteit Amsterdam, Anatomy and Neurosciences, De Boelelaan 1117, Amsterdam, the Netherlands.
Mult Scler Relat Disord. 2025 May;97:106407. doi: 10.1016/j.msard.2025.106407. Epub 2025 Mar 22.
To explore the associations between physical fitness and brain MRI-measures in people with secondary progressive MS (SPMS).
We assessed associations between physical fitness (i.e., cardiorespiratory fitness, leg muscle strength, and self-reported level of physical activity) and MRI-derived measures (i.e., brain volume, and resting-state functional (rsFC) of the default-mode network with the rest of the brain (DMN-brain) and sensorimotor network with the rest of the brain (SMN-brain)) using multiple linear regression analyses. Physical fitness was compared to published reference data, and MRI measures were compared to reference MRI data from healthy controls (HC) from Amsterdam UMC.
Twenty-nine participants with SPMS (median age 54 years (IQR:48-61), 69 % female) demonstrated lower physical fitness compared to published reference values, and reduced brain volume and rsFC of the SMN-brain compared to HC (n = 28, median age 54 (IQR:44-61, 64 % females). None of the associations between physical fitness and brain measures reached statistical significance (Bonferroni-adjusted). We observed two trends suggesting associations between: [1] better cardiorespiratory fitness and higher rsFC of the SMN-brain (b = 18,139.7, 95 %CI:86.4; 36,193.1), and [2] between higher self-reported level of physical activity and higher rsFC of the DMN-brain (b = 1810.2, 95 %CI:189.8; 3430.7).
In our cohort of 29 people with SPMS, no statistically significant associations were found between physical fitness and brain volumetric measures. A potential tendency towards associations were observed between better cardiorespiratory fitness and higher rsFC of the SMN-brain and higher self-reported level of physical activity and higher rsFC of the DMN-brain, suggesting a potential effect of physical fitness on functional brain connectivity in SPMS.
探讨继发进展型多发性硬化症（SPMS）患者的体能与脑部磁共振成像（MRI）测量指标之间的关联。
我们采用多元线性回归分析，评估了体能（即心肺适能、腿部肌肉力量和自我报告的身体活动水平）与MRI衍生指标（即脑容量、默认模式网络与大脑其他部分的静息态功能连接（rsFC）（DMN-大脑）以及感觉运动网络与大脑其他部分的静息态功能连接（SMN-大脑））之间的关联。将体能与已发表的参考数据进行比较，将MRI测量结果与来自阿姆斯特丹大学医学中心健康对照（HC）的参考MRI数据进行比较。
29名SPMS患者（中位年龄54岁（四分位间距：48 - 61岁），69%为女性）的体能低于已发表的参考值，与HC相比（n = 28，中位年龄54岁（四分位间距：44 - 61岁，64%为女性）），脑容量和SMN-大脑的rsFC降低。体能与脑部测量指标之间的关联均未达到统计学显著性（经Bonferroni校正）。我们观察到两个趋势，提示[1]较好的心肺适能与较高的SMN-大脑rsFC之间存在关联（b = 18,139.7，95%置信区间：86.4；36,193.1），以及[2]较高的自我报告身体活动水平与较高的DMN-大脑rsFC之间存在关联（b = 1810.2，95%置信区间：189.8；3430.7）。
在我们的29名SPMS患者队列中，未发现体能与脑容量测量指标之间存在统计学显著关联。观察到较好的心肺适能与较高的SMN-大脑rsFC以及较高的自我报告身体活动水平与较高的DMN-大脑rsFC之间存在潜在的关联趋势，提示体能对SPMS患者的脑功能连接可能有影响。
