Department of Radiology, Wan Fang Hospital, Taipei Medical University, Taipei, 116, Taiwan.
Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
BMC Psychiatry. 2024 Oct 10;24(1):671. doi: 10.1186/s12888-024-06112-4.
Individuals using methamphetamine (METH) may experience psychosis, which usually requires aggressive treatment. Studies of the neural correlates of METH-associated psychosis (MAP) have focused predominantly on the default mode network (DMN) and cognitive control networks. We hypothesize that METH use alters global functional connections in resting-state brain networks and that certain cross-network connections could be associated with psychosis.
We recruited 24 healthy controls (CRL) and 54 men with METH use disorder (MUD) who were then divided into 25 without psychosis (MNP) and 29 with MAP. Psychotic symptom severity was assessed using the Positive and Negative Syndrome Scale (PANSS), evaluating (1) large-scale alterations in regional-wise resting-state functional connectivity (rsFC) across 11 brain networks and (2) associations between rsFC and psychotic symptom severity.
The MUD group exhibited greater rsFC between the salience network (SN)-DMN, and subcortical network (SCN)-DMN compared to the CRL group. The MAP group exhibited decreased rsFC in the sensory/somatomotor network (SMN)-dorsal attention network (DAN), SMN-ventral attention network (VAN), SMN-SN, and SMN-auditory network (AN), whereas the MNP group exhibited increased rsFC in the SMN-DMN and the frontoparietal network (FPN)-DMN compared to CRL. Additionally, the MAP group exhibited decreased rsFC strength between the SMN-DMN, SMN-AN, SMN-FPN, and DMN-VAN compared to the MNP group. Furthermore, across the entire MUD group, the PANSS-Positive subscale was negatively correlated with the DMN-FPN and FPN-SMN, while the PANSS-Negative subscale was negatively correlated with the DMN-AN and SMN-SMN.
MUD is associated with altered global functional connectivity. In addition, the MAP group exhibits a different brain functional network compared to the MNP group.
使用甲基苯丙胺（METH）的个体可能会出现精神病，通常需要积极治疗。研究表明，METH 相关精神病（MAP）的神经相关性主要集中在默认模式网络（DMN）和认知控制网络上。我们假设 METH 使用改变了静息状态大脑网络的全局功能连接，并且某些跨网络连接可能与精神病有关。
我们招募了 24 名健康对照者（CRL）和 54 名 METH 使用障碍者（MUD），然后将他们分为 25 名无精神病（MNP）和 29 名有 MAP。使用阳性和阴性综合征量表（PANSS）评估精神病症状严重程度，评估（1）11 个大脑网络的区域静息态功能连接（rsFC）的大范围改变，以及（2）rsFC 与精神病症状严重程度之间的关联。
MUD 组的显著网络（SN）-DMN 和皮质下网络（SCN）-DMN 之间的 rsFC 大于 CRL 组。MAP 组的感觉/躯体运动网络（SMN）-背侧注意网络（DAN）、SMN-腹侧注意网络（VAN）、SMN-显著网络（SN）和 SMN-听觉网络（AN）的 rsFC 降低，而 MNP 组的 SMN-DMN 和额顶网络（FPN）-DMN 的 rsFC 高于 CRL。此外，MAP 组的 SMN-DMN、SMN-AN、SMN-FPN 和 DMN-VAN 之间的 rsFC 强度较 MNP 组降低。此外，在整个 MUD 组中，PANSS 阳性量表与 DMN-FPN 和 FPN-SMN 呈负相关，而 PANSS 阴性量表与 DMN-AN 和 SMN-SMN 呈负相关。
MUD 与改变的全局功能连接有关。此外，MAP 组与 MNP 组相比，大脑功能网络存在差异。
