Cavalhas-Almeida Catarina, Cristo Maria Inês, Cavadas Cláudia, Ramalho-Santos João, Álvaro Ana Rita, Amaral Sandra
CNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; CIBB - Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Portugal; Faculty of Pharmacy, University of Coimbra, Coimbra, Portugal.
CNC-UC - Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal; CIBB - Centre for Innovative Biomedicine and Biotechnology, University of Coimbra, Portugal; University of Coimbra, Institute for Interdisciplinary Research, Doctoral Programme in Experimental Biology and Biomedicine (PDBEB), Portugal.
Sleep Med Rev. 2025 Jun;81:102080. doi: 10.1016/j.smrv.2025.102080. Epub 2025 Mar 18.
Infertility affects millions of couples globally, with male factors contributing up to 50 % of cases. Despite the existing Assisted Reproduction Technologies (ART), decreased sperm quality and male infertility persist. Evidence suggests that sleep is crucial for normal reproductive function, and the noticeable increase in infertility rates aligns with the growing prevalence of sleep deprivation, suggesting a connection between both conditions. This literature review explores the possible links between sleep disturbances, with a special emphasis on insomnia, the most prevalent sleep disorder, and male reproductive health. It delves into the latest findings regarding factors such as sperm quality, hormone levels, and overall reproductive function from studies in mammals, both rodents and humans. Through a concise synthesis of these findings, we unveil potential mechanisms and provide crucial insights for clinicians and researchers in the field of reproductive health.
不孕症影响着全球数百万对夫妇，其中男性因素导致的病例占比高达50%。尽管现已有辅助生殖技术（ART），但精子质量下降和男性不育问题仍然存在。有证据表明，睡眠对正常生殖功能至关重要，而不孕症发病率的显著上升与睡眠剥夺患病率的不断增加相吻合，这表明两者之间存在关联。这篇文献综述探讨了睡眠障碍之间可能存在的联系，特别强调了失眠这一最普遍的睡眠障碍与男性生殖健康之间的关系。它深入研究了关于精子质量、激素水平和整体生殖功能等因素的最新研究结果，这些研究涵盖了啮齿动物和人类等哺乳动物。通过对这些研究结果的简要综合，我们揭示了潜在机制，并为生殖健康领域的临床医生和研究人员提供了重要见解。
