女性的睡眠、睡眠障碍与生育能力
Sleep, sleep disturbance, and fertility in women.
作者信息
Kloss Jacqueline D, Perlis Michael L, Zamzow Jessica A, Culnan Elizabeth J, Gracia Clarisa R
机构信息
Department of Psychology, Drexel University, USA.
Department of Psychiatry, Behavioral Sleep Medicine Program, University of Pennsylvania, USA.
出版信息
Sleep Med Rev. 2015 Aug;22:78-87. doi: 10.1016/j.smrv.2014.10.005. Epub 2014 Oct 18.
Abstract
Sleep and sleep disturbances are increasingly recognized as determinants of women's health and well-being, particularly in the context of the menstrual cycle, pregnancy, and menopause. At present, however, little is known about whether fertility is affected by sleep quantity and quality. That is, to what degree, and by what mechanisms, do sleep and/or its disturbances affect fertility? The purpose of this review is to synthesize what is known about sleep disturbances in relation to reproductive capacity. A model is provided, whereby stress, sleep dysregulation, and circadian misalignment are delineated for their potential relevance to infertility. Ultimately, if it is the case that sleep disturbance is associated with infertility, new avenues for clinical intervention may be possible.
摘要
睡眠及睡眠障碍越来越被视为女性健康和幸福的决定因素，尤其是在月经周期、怀孕和更年期的背景下。然而，目前对于生育能力是否受睡眠数量和质量的影响知之甚少。也就是说，睡眠和/或其障碍在何种程度上以及通过何种机制影响生育能力？本综述的目的是综合关于与生殖能力相关的睡眠障碍的已知信息。提供了一个模型，其中阐述了压力、睡眠失调和昼夜节律失调与不孕症潜在相关性。最终，如果睡眠障碍与不孕症相关，那么临床干预可能会有新的途径。
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2
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Semin Reprod Med. 2013 Nov;31(6):437-42. doi: 10.1055/s-0033-1356479. Epub 2013 Oct 7.
3
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J Clin Nurs. 2014 Jun;23(11-12):1677-84. doi: 10.1111/jocn.12306. Epub 2013 Jul 5.
4
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