Brooks Sarah G, Coscarella Giulia, Yosipovitch Gil
Dr Phillip Frost Department of Dermatology and Cutaneous Surgery, Miami Itch Center, University of Miami Miller School of Medicine, Miami, Florida, USA.
Dermatologia, Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, Rome, Italy; UOC di Dermatologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Rome, Italy.
Clin Dermatol. 2025 Mar 27. doi: 10.1016/j.clindermatol.2025.03.006.
Prurigo nodularis (PN) is a chronic inflammatory skin condition characterized by firm, itchy nodules and relentless itch. PN was first described in the 19th century. After observations of various dermatologists, the clinical presentation was officially given a name in 1909 by James Nevins Hyde. Throughout the 1900s, PN gained pockets of attention concerning its histopathologic features, epidemiology, and pathophysiology, although it existed as a largely ambiguous disease for many years. Only at the turn of the 21st century was the recognition of PN reignited, prompting extensive research and leading to striking advancements in our understanding of the mechanisms that had contributed to PN during the last decade. Despite a long and inconsistent course, there are now definitive immune and neural pathways that can be selectively targeted with novel therapies, suggesting a promising future for managing this debilitating condition.
结节性痒疹（PN）是一种慢性炎症性皮肤病，其特征为坚实、瘙痒的结节以及难以忍受的瘙痒。PN最早于19世纪被描述。在多位皮肤科医生进行观察之后，詹姆斯·内文斯·海德于1909年正式为其临床表现命名。在整个20世纪，尽管多年来PN在很大程度上一直是一种定义模糊的疾病，但它在组织病理学特征、流行病学和病理生理学方面受到了一些关注。直到21世纪之交，对PN的认识才再次被点燃，促使人们进行广泛研究，并在过去十年中使我们对导致PN的机制的理解取得了显著进展。尽管病程漫长且不一致，但现在有明确的免疫和神经通路可供新型疗法选择性地靶向，这表明在管理这种使人衰弱的疾病方面前景光明。
