Shi Yuxin, Zhang Hao, Miao Changhong
Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China.
Shanghai Key Laboratory of Perioperative Stress and Protection, Shanghai, China.
Cell Death Discov. 2025 Mar 28;11(1):123. doi: 10.1038/s41420-025-02403-1.
T cell metabolism and differentiation significantly shape the initiation, progression, and resolution of inflammatory responses. Upon activation, T cells undergo extensive metabolic shifts to meet distinct functional demands across various inflammatory stages. These metabolic alterations are not only critical for defining different T cell subsets, but also for sustaining their activity in inflammatory environments. Key signaling pathways-including mTOR, HIF-1α, and AMPK regulate these metabolic adaptions, linking cellular energy states with T cell fate decisions. Insights into the metabolic regulation of T cells offer potential therapeutic strategies to manipulate T cell function, with implications for treating autoimmune diseases, chronic inflammation, and cancer by targeting specific metabolic pathways.
T细胞代谢与分化显著影响炎症反应的起始、进展和消退。激活后，T细胞会经历广泛的代谢转变，以满足不同炎症阶段的独特功能需求。这些代谢改变不仅对于定义不同的T细胞亚群至关重要，而且对于维持它们在炎症环境中的活性也很关键。包括mTOR、HIF-1α和AMPK在内的关键信号通路调节这些代谢适应，将细胞能量状态与T细胞命运决定联系起来。对T细胞代谢调节的深入了解为操纵T细胞功能提供了潜在的治疗策略，对通过靶向特定代谢途径治疗自身免疫性疾病、慢性炎症和癌症具有重要意义。
