Li Xiufang, Heizhati Mulalibieke, Li Mei, Yao Ling, Wu Ting, Yang Wenbo, Gan Lin, Wang Hui, Liu Miaomiao, Maitituersun Adalaiti, Lin Mengyue, Hong Jing, Li Nanfang
Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hypertension Institute, HC Key Laboratory of Hypertension Clinical Research, Key Laboratory of Xinjiang Uygur Autonomous Region "Hypertension Research Laboratory", Xinjiang Clinical Medical Research Center for Hypertension (Cardio-Cerebrovascular) Disease, No. 91 Tianchi Road, Urumqi, 830001, Xinjiang, China.
Sci Rep. 2025 Mar 28;15(1):10817. doi: 10.1038/s41598-025-91538-3.
Sleep is implicated in circulating aldosterone, whereas effects of overall sleep quality are not characterized. Therefore, we explored relationship of sleep quality with plasma aldosterone concentration (PAC) in general population. We evaluated sleep quality using Pittsburgh sleep quality index (PSQI) and measured PAC in adults cross-sectionally. We divided participants into very good, fairly good, fairly bad and very bad sleepers, compared PAC and log-PAC, and applied linear regression to examine association of PSQI score with log-PAC, in total, gender- and age-stratified (young, middle-aged and old) participants. Sensitivity analysis were performed by excluding hypertension, sleep disordered breathing (SDB), or both. Among 29,499 participants, PAC showed significant increase from very good to very bad sleepers in total (14.3 vs. 14.4 vs. 14.7 vs. 15.8ng/dL), and in male participants (13.1 vs. 13.6 vs. 14.1 vs. 14.9ng/dL), consistent in the young and the middle-aged (P for all < 0.001) and in log PAC of total, in male and in different age groups (P for trend < 0.001). PSQI score showed significant positive association with log-PAC in total (B, 95%CI: 0.007, 0.003-0.010, P < 0.001) in male participants (0.013, 0.008-0.018, P < 0.001), consistent in the young and the middle-aged and in adjusted models. In female, PSQI score showed significant positive association with log-PAC in the old-aged. Sensitivity analysis yielded consistent observation with main analysis. Poor sleep quality is associated with elevated PAC, in young and middle-aged male and in elder female, independent of SDB and hypertension, indicating potential involvement of sleep quality on regulation of circulating aldosterone.
睡眠与循环中的醛固酮水平有关，而整体睡眠质量的影响尚不明确。因此，我们探讨了普通人群中睡眠质量与血浆醛固酮浓度（PAC）之间的关系。我们使用匹兹堡睡眠质量指数（PSQI）评估睡眠质量，并对成年人进行横断面PAC测量。我们将参与者分为睡眠质量非常好、较好、较差和非常差的组，比较PAC和log-PAC，并应用线性回归分析PSQI评分与log-PAC之间的关联，分析对象包括全部参与者、按性别分层（男性和女性）以及按年龄分层（年轻人、中年人、老年人）的参与者。通过排除高血压、睡眠呼吸障碍（SDB）或两者同时排除进行敏感性分析。在29499名参与者中，总体上PAC从睡眠质量非常好到非常差的参与者呈显著升高（14.3对14.4对14.7对15.8ng/dL），男性参与者中也是如此（13.1对13.6对14.1对14.9ng/dL），在年轻人和中年人中情况一致（所有P值均<0.001），在总体、男性及不同年龄组的log PAC中也是如此（趋势P值<0.001）。PSQI评分在总体上与log-PAC呈显著正相关（B，95%CI：0.007，0.003 - 0.010，P<0.001），在男性参与者中也是如此（0.013，0.008 - 0.018，P<0.001），在年轻人和中年人以及校正模型中情况一致。在女性中，PSQI评分在老年人中与log-PAC呈显著正相关。敏感性分析结果与主要分析一致。睡眠质量差与PAC升高有关，在年轻和中年男性以及老年女性中，独立于SDB和高血压，表明睡眠质量可能参与了循环醛固酮的调节。
