Nusufujiang Aketilieke, Heizhati Mulalibieke, Li Nanfang, Yao Ling, Yang Wenbo, Wang Hui, Li Mei, Gan Lin, Maitituersun Adalaiti, Liu Miaomiao, Nuermaimaiti Qiaolifanayi, Cai Li, Aierken Xiayire, Li Xiufang, Luo Qin, Hong Jing
Hypertension Center of People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hypertension Institute, NHC Key Laboratory of Hypertension Clinical Research, Key Laboratory of Xinjiang Uygur Autonomous Region "Hypertension Research Laboratory", Xinjiang Clinical Medical Research Center for Hypertension (Cardio-Cerebrovascular) Diseases, Ürümqi, China.
Front Nutr. 2025 Feb 6;12:1519644. doi: 10.3389/fnut.2025.1519644. eCollection 2025.
Aldosterone is the effector hormone in the renin angiotensin aldosterone system and existing data suggest aldosterone affect cognitive function. However, the relationship between plasma aldosterone concentration (PAC) and cognitive performance remains unexplored in community dwellers. Therefore, we aimed to explore whether PAC is associated with cognitive performance in this population.
We cross-sectionally enrolled adults using multistage random sampling from Emin, China in 2019. Participants underwent questionnaires and data collection. Cognitive status was assessed using mini-mental state examination (MMSE) questionnaire. Multi-variable linear and logistic regression were used to explore the association between log PAC and log MMSE score, and between tertiled PAC (the higher PAC as the exposure) and low cognitive performance, respectively, in total, apparently healthy and diseased participants. Subgroup analyses also were performed by age, gender, BMI, living region, ethnicity and education attainment status.
27,707 subjects were included, of whom, 12,862 were apparently healthy and 14,845 had disease. Log-PAC was positively associated with log-MMSE score in the multivariable linear regression in the total ( = 0.01, 95%CI: 0-0.01, < 0.001), apparently healthy ( = 0.01, 95%CI: 0-0.01, = 0.007) participants, and the diseased without taking medicine ( = 0.01, 95%CI: 0.01-0.02, = 0.004) participants. In logistic regression, the highest third tertile of PAC group showed significantly lower odds for the presence of low cognitive performance in total (OR = 0.83, 95%CI: 0.73-0.93, = 0.002) and diseased without taking medicine participants (OR = 0.70, 95%CI: 0.57-0.86, < 0.001). Various sub-group analysis showed largely consistent results with the main analysis.
There was a positive correlation between plasma aldosterone and cognitive functions in community dwellers, whereas further studies are need when considering the cross-sectional nature of the current study.
醛固酮是肾素-血管紧张素-醛固酮系统中的效应激素，现有数据表明醛固酮会影响认知功能。然而，社区居民血浆醛固酮浓度（PAC）与认知表现之间的关系仍未得到探索。因此，我们旨在探讨该人群中PAC是否与认知表现相关。
2019年，我们在中国峨山采用多阶段随机抽样方法对成年人进行横断面研究。参与者接受问卷调查并收集数据。使用简易精神状态检查表（MMSE）问卷评估认知状态。分别在全部、明显健康和患病参与者中，使用多变量线性回归和逻辑回归来探讨log PAC与log MMSE评分之间的关联，以及三分位数PAC（以较高PAC作为暴露因素）与低认知表现之间的关联。还按年龄、性别、BMI、居住地区、种族和教育程度进行了亚组分析。
共纳入27707名受试者，其中12862名明显健康，14845名患有疾病。在全部（β = 0.01，95%CI：0 - 0.01，P < 0.001）、明显健康（β = 0.01，95%CI：0 - 0.01，P = 0.007）参与者以及未服药的患病参与者（β = 0.01，95%CI：0.01 - 0.02，P = 0.004）的多变量线性回归中，log PAC与log MMSE评分呈正相关。在逻辑回归中，PAC组最高三分位数在全部人群（OR = 0.83，95%CI：0.73 - 0.93，P = 0.002）和未服药的患病参与者中（OR = 0.70，95%CI：0.57 - 0.86，P < 0.001）出现低认知表现的几率显著降低。各种亚组分析结果与主要分析结果基本一致。
社区居民血浆醛固酮与认知功能之间存在正相关，但考虑到本研究的横断面性质，仍需进一步研究。
