用于向牛眼给药的眼用植入剂——庆大霉素从胶原蛋白植入剂中释放的体外研究
Ocular inserts for application of drugs to bovine eyes--in vitro studies on gentamicin release from collagen inserts.
作者信息
Punch P I, Slatter D H, Costa N D, Edwards M E
出版信息
Aust Vet J. 1985 Mar;62(3):79-82. doi: 10.1111/j.1751-0813.1985.tb14143.x.
Abstract
Soluble collagen and insoluble collagen films were impregnated with gentamicin and investigated in vitro as vehicles for the delivery drugs. Succinylated collagen released significantly higher levels of antibiotic than the insoluble films, and maintained mean inhibitory concentrations (MIC) for Moraxella bovis for 24 h.
摘要
将可溶性胶原蛋白膜和不溶性胶原蛋白膜用庆大霉素浸渍，并作为药物递送载体进行体外研究。琥珀酰化胶原蛋白释放的抗生素水平明显高于不溶性膜，并对牛莫拉菌维持了24小时的平均抑菌浓度（MIC）。
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