比较接种和未接种新冠疫苗的孕妇的母婴结局：一项回顾性队列研究。
Comparing the maternal and neonatal outcomes in vaccinated and unvaccinated pregnant women against COVID-19: a retrospective cohort study.
作者信息
Gholami Zahra, Mohseni Maryam, Nasab Pouran Allahbakhshi
机构信息
Department of Midwifery, School of Nursing and Midwifery, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
Department of Midwifery, School of Nursing and Midwifery, Geriatric Care Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
出版信息
BMC Pregnancy Childbirth. 2025 Mar 28;25(1):367. doi: 10.1186/s12884-025-07462-x.
BACKGROUND
Following the emergence of COVID-19 disease, and considering the limited number of studies regarding vaccination among pregnant women, as well as the differences between the vaccine administered in Iran and those used in other countries, this study aimed to compare maternal and neonatal outcomes in vaccinated and unvaccinated women against COVID-19 disease.
METHODS
This retrospective cohort study was conducted at the comprehensive healthcare centers of Rafsanjan city. Initially, the contact information of expectant mothers who were pregnant between June 22, 2021, and December 22, 2021, was obtained through Iran's integrated healthcare system (Sib). Subsequently, the required information was collected via a checklist during phone interviews. Out of 969 pregnant women, after applying the inclusion and exclusion criteria, 610 subjects were included in the study. Among these, 330 were unvaccinated, while the remaining participants had received the inactivated COVID-19 vaccine prior to or during pregnancy. Maternal and neonatal outcomes were compared between vaccinated and unvaccinated women. Data analysis was performed using SPSS version 26, employing one-way analysis of variance (ANOVA), Tukey's multiple comparison test, Fisher's exact test, Chi-square test, and multiple logistic regression.
RESULTS
The findings indicated that vaccination against COVID-19 in pregnant women significantly increased the risk of neonatal jaundice (P < 0.05). Conversely, the miscarriage rate among these women was significantly lower (P < 0.05). No adverse outcomes were observed including hypertensive disorders, gestational diabetes, maternal hospitalization, maternal COVID-19 infection, preterm labor, premature rupture of membranes, perinatal mortality, admission to the neonatal intensive care unit, and low birth weight.
CONCLUSIONS
COVID-19 Vaccination is recommended for pregnant women to mitigate adverse neonatal and maternal outcomes.
背景
自新冠病毒病出现后，考虑到关于孕妇接种疫苗的研究数量有限，以及伊朗使用的疫苗与其他国家的疫苗存在差异，本研究旨在比较接种和未接种新冠病毒病疫苗的孕妇的母婴结局。
方法
本回顾性队列研究在拉夫桑詹市的综合医疗中心进行。最初，通过伊朗综合医疗系统（Sib）获取了2021年6月22日至2021年12月22日期间怀孕的准妈妈的联系信息。随后，通过电话访谈期间的一份清单收集所需信息。在969名孕妇中，应用纳入和排除标准后，610名受试者被纳入研究。其中，330名未接种疫苗，其余参与者在怀孕前或怀孕期间接种了新冠病毒灭活疫苗。比较接种和未接种疫苗的孕妇的母婴结局。使用SPSS 26版进行数据分析，采用单因素方差分析（ANOVA）、Tukey多重比较检验、Fisher精确检验、卡方检验和多重逻辑回归。
结果
研究结果表明，孕妇接种新冠病毒疫苗显著增加了新生儿黄疸的风险（P < 0.05）。相反，这些女性的流产率显著较低（P < 0.05）。未观察到不良结局，包括高血压疾病、妊娠期糖尿病、孕产妇住院、孕产妇新冠病毒感染、早产、胎膜早破、围产儿死亡、入住新生儿重症监护病房和低出生体重。
结论
建议孕妇接种新冠病毒疫苗以减轻不良的新生儿和孕产妇结局。
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