Hassani Nia Fatemeh, Wittamer Valerie
Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire Jacques E. Dumont, Brussels, Belgium.
ULB Neuroscience Institute, Université Libre de Bruxelles, Brussels, Belgium.
Dev Med Child Neurol. 2025 Oct;67(10):1257-1265. doi: 10.1111/dmcn.16317. Epub 2025 Mar 28.
Neurodevelopmental disorders (NDDs) are a group of brain disorders with a neonatal or early childhood onset and are lifelong. Various factors including genetics, and environmental and immune-related risk factors have been associated with NDDs. Given the complex nature of these disorders, multiple animal models have been used to investigate their aetiology and underlying cellular and molecular mechanisms. Recently, zebrafish have attracted great attention as an emerging model for studying NDDs. In addition to their easy maintenance, short developmental cycle, ex utero embryonic evolution, and optical clarity, zebrafish have successfully recapitulated phenotypes seen in human genetic disorders. This review explores the growing role of zebrafish in NDD research, by summarizing recently developed zebrafish genetic models for autism spectrum disorder, schizophrenia, and cerebral palsy. We then explore the potential of zebrafish as a model for studying NDDs linked to immune system dysfunction.
神经发育障碍（NDDs）是一组在新生儿期或幼儿期发病且伴随终身的脑部疾病。包括遗传因素以及与环境和免疫相关的危险因素在内的多种因素都与神经发育障碍有关。鉴于这些疾病的复杂性，人们使用了多种动物模型来研究其病因以及潜在的细胞和分子机制。最近，斑马鱼作为一种新兴的神经发育障碍研究模型受到了极大关注。除了易于饲养、发育周期短、胚胎在体外发育以及具有光学透明性外，斑马鱼还成功地再现了人类遗传疾病中出现的表型。本综述通过总结最近开发的用于自闭症谱系障碍、精神分裂症和脑瘫的斑马鱼遗传模型，探讨了斑马鱼在神经发育障碍研究中日益重要的作用。然后，我们探讨了斑马鱼作为研究与免疫系统功能障碍相关的神经发育障碍模型的潜力。
