Vaartjes W J, de Haas C G
Biochem Biophys Res Commun. 1985 Jun 28;129(3):721-6. doi: 10.1016/0006-291x(85)91951-5.
In hepatocytes isolated from meal-fed rats, phorbol 12-myristate 13-acetate as well as phorbol 12,13-didecanoate stimulated de novo fatty acid synthesis in a dose-dependent manner. Moreover, phorbol 12-myristate 13-acetate inhibited ketogenesis from exogenous oleate, but slightly enhanced oleate esterification. The stimulation of esterification was more pronounced with endogenously synthesized fatty acids. In hepatocytes from 24h-starved rats a moderate stimulation of gluconeogenesis and ureogenesis was observed with glutamine as substrate. It is concluded that tumor-promoting phorbol esters mimic the short-term effects of insulin on hepatic fatty acid metabolism.
在从进食后大鼠分离出的肝细胞中，佛波醇12 - 肉豆蔻酸酯13 - 乙酸酯以及佛波醇12,13 - 二十二烷酸酯以剂量依赖的方式刺激脂肪酸从头合成。此外，佛波醇12 - 肉豆蔻酸酯13 - 乙酸酯抑制外源性油酸的生酮作用，但略微增强油酸酯化。内源性合成脂肪酸的酯化刺激更为明显。在以谷氨酰胺为底物的24小时饥饿大鼠的肝细胞中，观察到糖异生和尿素生成有适度刺激。结论是，促肿瘤佛波醇酯模拟胰岛素对肝脏脂肪酸代谢的短期作用。
