促肿瘤佛波酯可增加大鼠脂肪细胞的基础脂肪生成并抑制胰岛素刺激的脂肪生成，而不会降低胰岛素结合。
Tumour-promoting phorbol esters increase basal and inhibit insulin-stimulated lipogenesis in rat adipocytes without decreasing insulin binding.
作者信息
van de Werve G, Proietto J, Jeanrenaud B
出版信息
Biochem J. 1985 Jan 15;225(2):523-7. doi: 10.1042/bj2250523.
Abstract
In isolated rat adipocytes, tumour-promoting phorbol esters caused (1) dose-dependent stimulation of lipogenesis in the absence of insulin and (2) inhibition of the lipogenic effect of submaximal concentrations of insulin, but without affecting insulin binding. The possible involvement of protein kinase C in insulin action is discussed.
摘要
在分离的大鼠脂肪细胞中，促肿瘤佛波酯导致：（1）在无胰岛素情况下剂量依赖性地刺激脂肪生成，以及（2）抑制次最大浓度胰岛素的脂肪生成作用，但不影响胰岛素结合。文中讨论了蛋白激酶C可能参与胰岛素作用的情况。
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Tumour-promoting phorbol esters increase basal and inhibit insulin-stimulated lipogenesis in rat adipocytes without decreasing insulin binding.促肿瘤佛波酯可增加大鼠脂肪细胞的基础脂肪生成并抑制胰岛素刺激的脂肪生成，而不会降低胰岛素结合。
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本文引用的文献
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Biologically active phorbol esters specifically alter affinity of epidermal growth factor membrane receptors.生物活性佛波醇酯特异性改变表皮生长因子膜受体的亲和力。
Nature. 1979 May 31;279(5712):387-91. doi: 10.1038/279387a0.
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Direct activation of calcium-activated, phospholipid-dependent protein kinase by tumor-promoting phorbol esters.肿瘤促进剂佛波酯对钙激活的、磷脂依赖性蛋白激酶的直接激活作用。
J Biol Chem. 1982 Jul 10;257(13):7847-51.
3
Inhibition of insulin receptor binding by phorbol esters.佛波酯对胰岛素受体结合的抑制作用。
Eur J Biochem. 1982 Dec 15;129(2):389-93. doi: 10.1111/j.1432-1033.1982.tb07062.x.
4
Affinity alteration of insulin receptor induced by a phorbol ester.佛波酯诱导的胰岛素受体亲和力改变
Am J Physiol. 1982 Oct;243(4):E319-24. doi: 10.1152/ajpendo.1982.243.4.E319.
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Phosphatidic acid and phosphatidylinositol labelling in adipose tissue. Relationship to the metabolic effects of insulin and insulin-like agents.脂肪组织中磷脂酸和磷脂酰肌醇的标记。与胰岛素及胰岛素样药物代谢作用的关系。
Biochem J. 1983 May 15;212(2):489-98. doi: 10.1042/bj2120489.
6
Insulin activates phospholipase C in fat cells: similarity with the activation of pyruvate dehydrogenase.胰岛素激活脂肪细胞中的磷脂酶C：与丙酮酸脱氢酶激活的相似性。
Mol Cell Endocrinol. 1984 Jun;36(1-2):123-9. doi: 10.1016/0303-7207(84)90091-1.
7
Insulin stimulation of phospholipid methylation in isolated rat adipocyte plasma membranes.胰岛素对分离的大鼠脂肪细胞质膜中磷脂甲基化的刺激作用。
Proc Natl Acad Sci U S A. 1984 Feb;81(4):1089-92. doi: 10.1073/pnas.81.4.1089.
8
The insulin receptor of a human monocyte-like cell line: characterization and function.人单核细胞样细胞系的胰岛素受体：特性与功能
Endocrinology. 1984 Jan;114(1):247-53. doi: 10.1210/endo-114-1-247.
9
The mechanism of action of insulin on phospholipid metabolism in rat adipose tissue. Requirement for protein synthesis and a carbohydrate source, and relationship to activation of pyruvate dehydrogenase.胰岛素对大鼠脂肪组织磷脂代谢的作用机制。蛋白质合成和碳水化合物来源的需求，以及与丙酮酸脱氢酶激活的关系。
Diabetes. 1984 Jul;33(7):648-55. doi: 10.2337/diab.33.7.648.
10
Protein phosphorylation and mechanism of action of tumor-promoting phorbol esters.蛋白质磷酸化与促肿瘤佛波酯的作用机制
Adv Cyclic Nucleotide Protein Phosphorylation Res. 1984;17:437-42.
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