Kosareva O S, Drovosekov M N, Savchenko S V, Ageeva T A, Ivanova N A, Ostapets S V, Nikitenko E V
Novosibirsk State Medical University, Ministry of Health of the Russian Federation, Novosibirsk, Russia.
City Clinical Hospital No. 1, Novosibirsk, Russia.
Bull Exp Biol Med. 2025 Feb;178(4):547-551. doi: 10.1007/s10517-025-06371-5. Epub 2025 Mar 29.
Bone volume restoration is of particular importance when planning orthopedic treatment based on dental implants. Bone deficiency resulting from tooth loss, injuries, jaw neoplasms, or inflammatory diseases excludes the possibility of implant placement without special preparation. Autograft is the "gold standard" of osteoplastic material, but the limited volume and additional traumatization make it difficult to use. Prospects for the restoration of bone defects are opened by a 3D tissue-engineered osteograft obtained by direct differentiation from a chondrograft in an osteogenic medium in vitro, which is osteogenic tissue with high regenerative potential.
在基于牙种植体规划骨科治疗时，骨量恢复尤为重要。由牙齿缺失、损伤、颌骨肿瘤或炎症性疾病导致的骨缺损排除了在没有特殊准备的情况下进行种植体植入的可能性。自体骨移植是骨塑性材料的“金标准”，但其有限的体积和额外的创伤使其难以使用。通过在体外成骨培养基中从软骨移植直接分化获得的3D组织工程骨移植为骨缺损的修复开辟了前景，这种骨移植是具有高再生潜力的成骨组织。
