Turan Ozerk, Garner Jonathan, Isaiah Amal, Palatino Maylin, Ernst Thomas, Wang Ze, Chang Linda
University of Maryland School of Medicine, Baltimore, MD, United States.
Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, Baltimore, MD, United States.
Sleep. 2025 Mar 29. doi: 10.1093/sleep/zsaf088.
Adolescents often do not sleep as much as recommended by most national guidelines, which may impact their brain development. The current study aims to evaluate the relationship between objective assessment of sleep duration measured with actigraphy, and brain network connectivity on functional magnetic resonance imaging (fMRI).
We used data from the two-year follow-up of the Adolescent Brain Cognitive Development (ABCD) study comprising 3,799 adolescents, ages 10 to 13 years old, to assess the relationship between sleep duration, measured by two weeks of Fitbit-derived actigraphy, and brain network connectivity derived from resting-state fMRI, using linear regression models. Linear regression analysis was also used to investigate the interaction between participant sex and sleep duration on brain network connectivity.
We identified both positive and negative correlations between mean sleep duration and 6 within brain network and 30 between-network pairs. These included networks involved in attention (Dorsal and Ventral Attention networks), executive control (Cingulo-Opercular and Default Mode networks), memory (Retrosplenial Temporal network), and sensory function (Auditory and Sensorimotor networks). We also identified sex-specific effects in three network pairs (Auditory - Retrosplenial Temporal, Retrosplenial Temporal - Sensorimotor, and Visual - Visual) and sex differences in functional connectivity across 23 distinct within- and between-network connections.
Sleep duration is associated with the functional network connectivity in attentional, executive control, memory, and sensory networks during early adolescence. The identification of sex-specific effects in select network pairs underscores the importance of sex as a biological variable in studies of adolescent sleep and brain development.
青少年的睡眠时间往往达不到大多数国家指南的建议，这可能会影响他们的大脑发育。本研究旨在评估通过活动记录仪进行的睡眠时间客观评估与功能磁共振成像（fMRI）上的脑网络连通性之间的关系。
我们使用了青少年大脑认知发展（ABCD）研究两年随访的数据，该研究包括3799名10至13岁的青少年，通过线性回归模型评估由两周的Fitbit活动记录仪测量的睡眠时间与静息态fMRI得出的脑网络连通性之间的关系。线性回归分析还用于研究参与者性别和睡眠时间对脑网络连通性的交互作用。
我们确定了平均睡眠时间与6个脑内网络和30个脑间网络对之间的正相关和负相关。这些网络包括参与注意力（背侧和腹侧注意力网络）、执行控制（扣带- opercular和默认模式网络）、记忆（ retrosplenial颞叶网络）和感觉功能（听觉和感觉运动网络）的网络。我们还确定了三个网络对（听觉- retrosplenial颞叶、retrosplenial颞叶-感觉运动和视觉-视觉）中的性别特异性效应以及23个不同的脑内和脑间连接的功能连通性中的性别差异。
在青春期早期，睡眠时间与注意力、执行控制、记忆和感觉网络中的功能网络连通性相关。在选定的网络对中确定性别特异性效应强调了性别作为青少年睡眠和大脑发育研究中的一个生物学变量的重要性。
