O'Shaughnessy C, Poat J A, Turnbull M J
Biochem Pharmacol. 1985 Aug 1;34(15):2675-7. doi: 10.1016/0006-2952(85)90566-0.
In the rat striatum sulphated CCK8 has no significant effect on equilibrium binding of 3H-spiperone but has a considerable, although transient, effect under non-equilibrium conditions. Under non-equilibrium conditions (during the association phase of ligand binding) and at high ligand concentrations (1 nM), CCK8 displaces specific binding and at low ligand concentrations (0.1 nM) CCK8 enhances specific binding. CCK8 has no effect on 3H-spiperone dissociation kinetics.
在大鼠纹状体中，硫酸化的CCK8对3H-螺哌隆的平衡结合没有显著影响，但在非平衡条件下有相当大的影响，尽管这种影响是短暂的。在非平衡条件下（配体结合的缔合阶段）以及高配体浓度（1 nM）时，CCK8取代特异性结合，而在低配体浓度（0.1 nM）时，CCK8增强特异性结合。CCK8对3H-螺哌隆的解离动力学没有影响。
