胆囊收缩素对大鼠纹状体多巴胺能机制的影响。
The effects of cholecystokinin on dopaminergic mechanisms in rat striatum.
作者信息
Mashal R D, Owen F, Deakin J F, Poulter M
出版信息
Brain Res. 1983 Oct 31;277(2):375-6. doi: 10.1016/0006-8993(83)90949-6.
PMID:6315150
Abstract
Intraventricular administration of cholecystokinin-octapeptide in unanesthetized rats results in a significant reduction in the number of [3H]spiperone binding sites. Striatal levels of the dopamine metabolites 3,4-dihydroxyphenylacetic acid and homovanillic acid were significantly reduced, whereas there was no significant reduction in the levels of the serotonin metabolite 5-hydroxyindoleacetic acid.
摘要
在未麻醉的大鼠中脑室内注射八肽胆囊收缩素会导致[3H]司哌隆结合位点数量显著减少。纹状体中多巴胺代谢物3,4-二羟基苯乙酸和高香草酸的水平显著降低，而血清素代谢物5-羟吲哚乙酸的水平则没有显著降低。
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