Abbas Marwa F, Karim Dhuha K, Kareem Huda Raad, Kamil Marwa M, Al-Musawi Mastafa H, Asker Mohammed Hayder, Ghanami Maral, Shahriari-Khalaji Mina, Sattar Mamoona, Mirhaj Marjan, Sharifianjazi Fariborz, Tavamaishvili Ketevan, Mohabbatkhah Mehdi, Soheily Ali, Noory Parastoo, Tavakoli Mohamadreza
Department of Clinical Laboratory Sciences, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq.
Department of Pharmaceutics, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq.
Carbohydr Polym. 2025 Jun 1;357:123468. doi: 10.1016/j.carbpol.2025.123468. Epub 2025 Mar 1.
Fucoidan, a sulfated polymeric carbohydrate isolated from various marine brown algae, has attracted the interest of biomedical scientists because of its unique structural features and extensive spectrum of biological activity. This review encompasses a comprehensive insight into fucoidan's extraction procedures, cross-linking strategies, chemical modifications, and biomedical applications. Advanced extraction methods, such as microwave-assisted and enzyme-assisted extraction, are emphasized to get high-quality fucoidan that has augmented bioactivity. Moreover, the production and role of fucoidan-based materials in drug delivery systems are investigated, with a focus on their potential for targeted therapies. The study also explores the strategies to improve fucoidan's bioavailability and mechanical properties via structural modifications, such as Sulfation, desulfation, methylation, benzoylation, sulfation, amination, acetylation and phosphorylation, and cross-linking with other polymers to form films, hydrogels, and nanocomposites. In addition, fucoidan's applications in drug delivery systems, tissue engineering, microneedles, and 3D bioprinting are discussed. By summarizing current research findings, this study seeks to comprehend the mechanisms underpinning fucoidan's therapeutic efficacy and its potential to develop robust biomaterials.
岩藻依聚糖是一种从各种海洋褐藻中分离出来的硫酸化聚合碳水化合物，因其独特的结构特征和广泛的生物活性谱而引起了生物医学科学家的关注。这篇综述全面深入地探讨了岩藻依聚糖的提取方法、交联策略、化学修饰及其生物医学应用。文中强调了先进的提取方法，如微波辅助提取和酶辅助提取，以获得具有增强生物活性的高质量岩藻依聚糖。此外，还研究了基于岩藻依聚糖的材料在药物递送系统中的生产和作用，重点关注其在靶向治疗方面的潜力。该研究还探索了通过结构修饰（如硫酸化、去硫酸化、甲基化、苯甲酰化、胺化、乙酰化和磷酸化）以及与其他聚合物交联形成薄膜、水凝胶和纳米复合材料来提高岩藻依聚糖生物利用度和机械性能的策略。此外，还讨论了岩藻依聚糖在药物递送系统、组织工程、微针和3D生物打印中的应用。通过总结当前的研究结果，本研究旨在理解岩藻依聚糖治疗效果的潜在机制及其开发强大生物材料的潜力。
