Jia Haifu, Li Yuanyuan, Zheng Yaping, Wang Huabing, Zhao Feng, Yang Xinyan, Zhao Qianyu, Jiang Yujun, Man Chaoxin
Key Laboratory of Dairy Science, Ministry of Education, College of Food Science, Northeast Agricultural University, Harbin 150030, China.
Key Laboratory of Dairy Science, Ministry of Education, College of Food Science, Northeast Agricultural University, Harbin 150030, China; Key Laboratory of Infant Formula Food, State Administration for Market Regulation, Harbin 150030, China.
Carbohydr Polym. 2025 Mar 15;352:123183. doi: 10.1016/j.carbpol.2024.123183. Epub 2024 Dec 26.
Consumer demand for nutritional supplements has fueled the rapid growth of the functional food market. However, ensuring the stability of functional factors in harsh environments remains a major challenge. The development of encapsulation systems is regarded as an effective method for enhancing the stability of functional factors, encapsulation carriers can offer protection for these functional factors. However, the selection of materials remains a significant constraint in the construction of delivery systems. Therefore, developing new encapsulation materials is crucial for advancing delivery systems, preserving the stability of functional factors, and ensuring public health. Fucoidan, a sulfated marine polysaccharide, has garnered significant attention in the field of encapsulation due to its notable advantages, including its remarkable bioactivity, biocompatibility, and targeted binding properties. Fucoidan-improved delivery systems provide new strategies for encapsulation of functional factors. This review first describes the structure of fucoidan, its modification and lists the applications of modified fucoidan, and assesses its feasibility for enhancing delivery systems. Second, it summarizes several common encapsulation technologies and methods, and outlines various carrier types based on fucoidan. Finally, it elucidates recent advances in the biomedical applications of fucoidan-improved delivery systems. Notably, it also presents the challenges and future prospects of this promising field.
消费者对营养补充剂的需求推动了功能性食品市场的快速增长。然而，在恶劣环境中确保功能因子的稳定性仍然是一项重大挑战。包封系统的开发被认为是提高功能因子稳定性的有效方法，包封载体可以为这些功能因子提供保护。然而，材料的选择仍然是构建递送系统的一个重大限制因素。因此，开发新型包封材料对于推进递送系统、保持功能因子的稳定性以及确保公众健康至关重要。岩藻依聚糖是一种硫酸化海洋多糖，因其显著的优势，包括卓越的生物活性、生物相容性和靶向结合特性，在包封领域受到了广泛关注。岩藻依聚糖改进的递送系统为功能因子的包封提供了新策略。本综述首先描述了岩藻依聚糖的结构、其修饰情况并列举了修饰岩藻依聚糖的应用，评估了其增强递送系统的可行性。其次，总结了几种常见的包封技术和方法，并概述了基于岩藻依聚糖的各种载体类型。最后，阐明了岩藻依聚糖改进的递送系统在生物医学应用方面的最新进展。值得注意的是，还介绍了这一充满前景的领域所面临的挑战和未来前景。
