Recent advances in fucoidan-based improved delivery systems: Structure, carrier types and biomedical applications.

Consumer demand for nutritional supplements has fueled the rapid growth of the functional food market. However, ensuring the stability of functional factors in harsh environments remains a major challenge. The development of encapsulation systems is regarded as an effective method for enhancing the stability of functional factors, encapsulation carriers can offer protection for these functional factors. However, the selection of materials remains a significant constraint in the construction of delivery systems. Therefore, developing new encapsulation materials is crucial for advancing delivery systems, preserving the stability of functional factors, and ensuring public health. Fucoidan, a sulfated marine polysaccharide, has garnered significant attention in the field of encapsulation due to its notable advantages, including its remarkable bioactivity, biocompatibility, and targeted binding properties. Fucoidan-improved delivery systems provide new strategies for encapsulation of functional factors. This review first describes the structure of fucoidan, its modification and lists the applications of modified fucoidan, and assesses its feasibility for enhancing delivery systems. Second, it summarizes several common encapsulation technologies and methods, and outlines various carrier types based on fucoidan. Finally, it elucidates recent advances in the biomedical applications of fucoidan-improved delivery systems. Notably, it also presents the challenges and future prospects of this promising field.