Hernández-García Javier, Muro-Reche Patricia, Orenes-Piñero Esteban
Department of Biochemistry and Molecular Biology-A, University of Murcia, Avda. de las Fuerzas Armadas, S/N, Lorca, 30800, Murcia, Spain.
Mol Cell Biochem. 2025 Mar 31. doi: 10.1007/s11010-025-05271-6.
The gut microbiota can affect both the enteric and the central nervous system, influencing individuals and their brain regulation. In this work, different pieces of scientific evidence are discussed, showing the relationship between changes in the microbiota and neurocognitive deterioration, focussing on Parkinson's disease (PD). Other factors that may cause or contribute to PD aetiology are the interactions between environmental factors and genetic susceptibility. According to the existing literature, there are several methods for the identification of neurocognitive impairment in different neurological diseases. However, such methods do not allow early identification, and therefore, the possibility of using other types of more effective diagnostic biomarkers in PD has also been investigated. Since this disease is characterised by specific microRNA (miRNA) expression, and the gut microbiota is an important factor in both PD and miRNA expression, the aim of this review is thoroughly analysing the role of microbiota and microRNAs in PD development. In addition, the relationship between these two factors and potential treatments will be also discussed.
肠道微生物群可影响肠道和中枢神经系统，对个体及其大脑调节产生影响。在这项研究中，我们讨论了不同的科学证据，展示了微生物群变化与神经认知衰退之间的关系，重点关注帕金森病（PD）。可能导致或促成PD病因的其他因素是环境因素与遗传易感性之间的相互作用。根据现有文献，有几种方法可用于识别不同神经系统疾病中的神经认知障碍。然而，这些方法无法实现早期识别，因此，人们也对在PD中使用其他类型更有效的诊断生物标志物的可能性进行了研究。由于这种疾病的特征是特定的微小RNA（miRNA）表达，并且肠道微生物群是PD和miRNA表达的重要因素，本综述的目的是全面分析微生物群和微小RNA在PD发展中的作用。此外，还将讨论这两个因素与潜在治疗方法之间的关系。
