Islam M S, Roy A S, Raza A K M, Miah M O F, Khan S R, Salahuddin A Z M, Datta P, Firoz M N H, Islam H
Dr Md Saiful Islam, Resident Nephrology, Department of Nephrology, Mymensingh Medical College (MMC), Mymensingh, Bangladesh; E-mail:
Mymensingh Med J. 2025 Apr;34(2):554-561.
High sensitivity C-reactive protein (hs-CRP) is a well-characterized marker of low grade systemic inflammation. Microalbuminuria is an established marker of vascular endothelial damage. There are evidences that nephropathy in type 2 diabetics develops due to sustained chronic low grade inflammation and vascular endothelial dysfunction. The objective of the study was to find out the association of serum high sensitivity C-reactive protein (hs-CRP) levels with microalbuminuria in type 2 diabetic patients. This cross-sectional observational study was carried out in outpatient departments of Nephrology and Endocrinology of Mymensingh Medical College Hospital, Mymensingh. One hundred (100) type 2 diabetic patients in the age group 30 to 70 years with at least one year duration were included in the study. FBS, Serum creatinine, Serum hs-CRP level and Albumin-creatinine ratio (ACR) were measured in these subjects. It was observed that higher level of hs-CRP found in subjects with microalbuminuria. Majority (93.2%) were with microalbuminuria >50mg/gm with hs-CRP >3mg/L. There is statistically significant association between microalbuminuria and hs-CRP (p<0.001). The Pearson correlation test also showed positive correlation between hs-CRP level and microalbuminuria (r=0.876; p<0.001). There were also statistically significant (p<0.05) relationship between microalbuminuria and FBS, HbA1c as well as serum creatinine. This study concludes that microalbuminuria accompanied by elevated hs-CRP in Type 2 diabetic patient suggesting activation of inflammatory pathways. The importance of early detection, monitoring of inflammatory marker hs-CRP and ACR as predictors of diabetic nephropathy can help in modulating diabetes and its complications.
高敏C反应蛋白（hs-CRP）是一种已被充分表征的低度全身炎症标志物。微量白蛋白尿是血管内皮损伤的既定标志物。有证据表明，2型糖尿病患者的肾病是由于持续的慢性低度炎症和血管内皮功能障碍所致。本研究的目的是探讨2型糖尿病患者血清高敏C反应蛋白（hs-CRP）水平与微量白蛋白尿之间的关联。这项横断面观察性研究在迈门辛医学院医院的肾病科和内分泌科门诊进行。研究纳入了100例年龄在30至70岁、病程至少1年的2型糖尿病患者。对这些受试者测量了空腹血糖（FBS）、血清肌酐、血清hs-CRP水平和白蛋白-肌酐比值（ACR）。观察发现，微量白蛋白尿患者的hs-CRP水平较高。大多数（93.2%）微量白蛋白尿>50mg/g且hs-CRP>3mg/L。微量白蛋白尿与hs-CRP之间存在统计学显著关联（p<0.001）。Pearson相关性检验也显示hs-CRP水平与微量白蛋白尿之间呈正相关（r=0.876；p<0.001）。微量白蛋白尿与FBS、糖化血红蛋白（HbA1c）以及血清肌酐之间也存在统计学显著（p<0.05）关系。本研究得出结论，2型糖尿病患者微量白蛋白尿伴有hs-CRP升高提示炎症途径被激活。早期检测、监测炎症标志物hs-CRP和ACR作为糖尿病肾病预测指标的重要性有助于调节糖尿病及其并发症。
