Department of Endocrinology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Department of Orthopedics, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
J Diabetes Res. 2021 Feb 9;2021:8862573. doi: 10.1155/2021/8862573. eCollection 2021.
Brachial-ankle pulse wave velocity (baPWV) has been shown to correlate with a host of disorders associated with arterial stiffness. Type 2 diabetes is associated with the involvement of both small vessels and large vessels. Studies on the relevance of baPWV to early diabetic nephropathy are scarce. This retrospective observational case-control study enrolled 120 patients with type 2 diabetes from our medical records. We classified patients into two groups depending on the magnitude of albuminuria: 60 patients with microalbuminuria were classified as the early diabetic nephropathy group (EDN group) and 60 patients without albuminuria were classified as the diabetes without nephropathy group (DWN group). An additional 30 nondiabetic age- and sex-matched controls were also enrolled. Data regarding the lipid profile, blood pressure, baPWV, high-sensitivity C reactive protein (hs-CRP) level, anthropometric measurements, urine albumin/creatinine ratio (UACR), serum creatinine level, and glycemic control indices (i.e., fasting plasma glucose (FPG), postprandial glucose (PPG), and glycosylated hemoglobin (hemoglobin A1c, HbA1c)) were recorded for all enrolled participants. baPWV was significantly higher in the EDN group than in the DWN group. Moreover, baPWV was positively correlated with age, duration of diabetes, obesity, poor glycemic control, and high serum levels of triglycerides (TG), hs-CRP, creatinine, and uric acid as well as a high UACR (all < 0.01). A significant negative correlation was found between baPWV and high-density lipoprotein levels ( < 0.05). Multivariate regression analysis showed that the hs-CRP level and duration of diabetes most strongly influenced baPWV. baPWV may be a convenient, noninvasive, and reproducible method for detecting early diabetic nephropathy.
肱踝脉搏波速度（baPWV）与多种与动脉僵硬度相关的疾病有关。2 型糖尿病与小血管和大血管的病变都有关。关于 baPWV 与早期糖尿病肾病相关性的研究很少。本回顾性观察性病例对照研究纳入了我们病历中的 120 名 2 型糖尿病患者。我们根据蛋白尿的程度将患者分为两组：60 名微量白蛋白尿患者被归类为早期糖尿病肾病组（EDN 组），60 名无蛋白尿患者被归类为无糖尿病肾病组（DWN 组）。另外还纳入了 30 名非糖尿病、年龄和性别匹配的对照者。记录了所有纳入参与者的血脂谱、血压、baPWV、高敏 C 反应蛋白（hs-CRP）水平、人体测量学指标、尿白蛋白/肌酐比值（UACR）、血清肌酐水平和血糖控制指标（即空腹血糖（FPG）、餐后血糖（PPG）和糖化血红蛋白（HbA1c））。EDN 组的 baPWV 明显高于 DWN 组。此外，baPWV 与年龄、糖尿病病程、肥胖、血糖控制不佳以及血清三酰甘油（TG）、hs-CRP、肌酐和尿酸水平升高以及 UACR 升高呈正相关（均 <0.01）。baPWV 与高密度脂蛋白水平呈显著负相关（<0.05）。多变量回归分析显示，hs-CRP 水平和糖尿病病程对 baPWV 的影响最大。baPWV 可能是一种方便、无创且可重复的检测早期糖尿病肾病的方法。
