Baral Tejaswini, Johnson Aieshel Serafin, Unnikrishnan Mazhuvancherry Kesavan, Manu Mohan K, Saravu Kavitha, Udyavara Kudru Chandrashekar, Abdulsalim Suhaj, Singh Jitendra, Mukhopadhyay Chiranjay, Rao Mahadev, Miraj Sonal Sekhar
Department of Pharmacy Practice, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, India.
Department of Pharmacy Practice, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, Kochi, India.
Expert Opin Ther Targets. 2025 Mar;29(3):171-178. doi: 10.1080/14728222.2025.2482548. Epub 2025 Mar 31.
Indole-3-propionic acid (IPA), a tryptophan catabolite derived from gut bacterial metabolism, has been identified as a functional link between the gut microbiome and tuberculosis.
IPA has gained ample attention over the past two decades on account of its multiple physiological roles, besides being both detectable and quantifiable. IPA is well studied across different health conditions, including cardiovascular and neurological conditions. IPA blocks tryptophan synthesis in Mycobacterium by binding to the allosteric tryptophan-binding site of TrpE, thereby threatening Mycobacterium survival due to tryptophan deficit.
Characterizing IPA would enable its use as a tool to investigate the pathophysiology of tuberculosis. Integrating 'OMICS' techniques (through next-generation sequencing) along with targeted microbial metabolomics may help explore the possible association of serum IPA levels with TB in patients. This will aid in identifying IPA-producing gut microbes and selecting probiotic strains as a microbiome-targeting adjunct therapy, eventually enhancing our understanding of the molecular dynamics of the pathophysiology of tuberculosis in the context of the microbiome.
吲哚 - 3 - 丙酸（IPA）是一种源自肠道细菌代谢的色氨酸分解代谢产物，已被确定为肠道微生物群与结核病之间的功能联系。
在过去二十年中，IPA因其多种生理作用以及可检测和可量化的特性而备受关注。IPA在包括心血管和神经疾病在内的不同健康状况下都得到了充分研究。IPA通过与TrpE的变构色氨酸结合位点结合，阻断分枝杆菌中的色氨酸合成，从而因色氨酸缺乏威胁分枝杆菌的生存。
对IPA进行表征将使其能够用作研究结核病病理生理学的工具。将“组学”技术（通过下一代测序）与靶向微生物代谢组学相结合，可能有助于探索患者血清IPA水平与结核病之间的可能关联。这将有助于识别产生IPA的肠道微生物，并选择益生菌菌株作为针对微生物群的辅助治疗，最终增进我们对微生物群背景下结核病病理生理学分子动力学的理解。
