Lv Hailin, Liu Zhen, Sun Mengjia, Yu Shiyong, Hu Mingdong, Bian Shizhu, Ye Xiaowei, Wang Ke, Dong Hongmei, Yang Bingjie, Zhou Chao, Huang Lan, Yang Jie
Institute of Cardiovascular Diseases of PLA, the Second Affiliated Hospital, Army Medical University, Chongqing, China.
Department of Cardiology, the Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, P.R. China.
iScience. 2025 Feb 27;28(3):112112. doi: 10.1016/j.isci.2025.112112. eCollection 2025 Mar 21.
The dynamic characteristics of cardiorespiratory fitness during high-altitude acclimatization and deacclimatization are not well elucidated, and whether ubiquinol exerts beneficial effects on cardiorespiratory fitness remains debated. In this trial, 41 volunteers were randomized to receive oral ubiquinol or placebo administration, 14 days before departure to highlands. All individuals were carried to 3900 m by air and then returned to 300 m after 7 days. Cardiopulmonary exercise testing was performed at baseline, on the third day after arrival in the highlands, and on the seventh day after return. This trial revealed the dynamic characteristics of cardiorespiratory fitness during the entire high-altitude acclimatization and deacclimatization process. The short-term journey to the highlands did not significantly affect cardiorespiratory fitness or physical performance capacity after the return. Cardiovascular and respiratory recoveries were desynchronized after returning from the highlands. Ubiquinol supplementation maintained the physical performance capacity in the highlands and facilitated acclimatization to hypoxia. Trial registration: The Chinese Clinical Trial Registry, ChiCTR2200059900, http://www.chictr.org.cn/ChiCTR2200059900.
高海拔适应和脱适应过程中心肺适能的动态特征尚未得到充分阐明，泛醇是否对心肺适能产生有益影响仍存在争议。在本试验中，41名志愿者在出发前往高原前14天被随机分为口服泛醇组或安慰剂组。所有人均乘飞机抵达3900米，7天后返回300米。在基线、抵达高原后第三天和返回后第七天进行心肺运动测试。本试验揭示了整个高海拔适应和脱适应过程中心肺适能的动态特征。前往高原的短期行程对返回后的心肺适能或身体运动能力没有显著影响。从高原返回后，心血管和呼吸恢复不同步。补充泛醇可维持高原地区的身体运动能力，并促进对缺氧的适应。试验注册：中国临床试验注册中心，ChiCTR2200059900，http://www.chictr.org.cn/ChiCTR2200059900 。
