He Xiaoying, Xiao Jingyi, Wang Yan, Reid Christopher, Xu Dan, Hong Hua
The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
CCRE, Curtin School of Population Health, Faculty of Health Sciences, Curtin University, Australia.
Int J Cardiol Cardiovasc Risk Prev. 2025 Mar 8;25:200394. doi: 10.1016/j.ijcrp.2025.200394. eCollection 2025 Jun.
To examine the association between dyslipidemia and cerebral atrophy in Chinese health check-up population.
67,526 participants underwent routine health check-ups at the health management center of the First Affiliated Hospital of Sun Yat-Sen University (FAH-SYSU) in Guangzhou for two years (2022-2023) in this cross-sectional study. Cerebral atrophy was determined by expert physicians based on non-contrast scans of Head Magnetic Resonance Imaging (MRI), Magnetic Resonance Angiography (MRA) and/or Head Computed Tomography (CT). The levels of Total Cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) were measured and classified by quartiles into four categories, respectively. The multivariable logistic regression model was used to obtain the odds ratios (ORs) and 95% confidence intervals (CIs).
A total of 1,661 participants were included with ages from 18 to 93 years. Among 1,661 participants, 121 (7.28%) had cerebral atrophy. On multivariate analysis, TC and LDL-C were not associated with cerebral atrophy, although TC and LDL-C were lower in the subgroup with cerebral atrophy.
This cross-sectional study conducted in China is the first to identify that health check-up examinees with cerebral atrophy had lower levels of TC and LDL-C raising the possible association between lower levels of TC and LDL-C with cerebral atrophy, and possible cognitive dysfunction. Future study is planned to overcome the existing limitation and address the lack of statistically significant association between TC and LDL-C levels with cerebral atrophy and possible dementia.
探讨中国健康体检人群中血脂异常与脑萎缩之间的关联。
在这项横断面研究中，67526名参与者于2022年至2023年期间在广州中山大学附属第一医院健康管理中心接受了为期两年的常规健康体检。脑萎缩由专家医生根据头部磁共振成像（MRI）、磁共振血管造影（MRA）和/或头部计算机断层扫描（CT）的非增强扫描结果确定。测量总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）和甘油三酯（TG）水平，并分别按四分位数分为四类。采用多变量逻辑回归模型获得比值比（OR）和95%置信区间（CI）。
共纳入1661名年龄在18至93岁之间的参与者。在1661名参与者中，121名（7.28%）患有脑萎缩。多因素分析显示，TC和LDL-C与脑萎缩无关，尽管脑萎缩亚组中的TC和LDL-C水平较低。
在中国进行的这项横断面研究首次发现，患有脑萎缩的健康体检者TC和LDL-C水平较低，这提示TC和LDL-C水平较低与脑萎缩以及可能的认知功能障碍之间可能存在关联。计划开展进一步研究以克服现有局限性，并解决TC和LDL-C水平与脑萎缩及可能的痴呆之间缺乏统计学显著关联的问题。
