Stroud C M, Noden P F, Whitsett J M
Biol Reprod. 1985 Jun;32(5):1191-9. doi: 10.1095/biolreprod32.5.1191.
The role of prolactin during sexual maturation in male golden hamsters was studied. Controls (n = 23) received vehicle and treated animals (n = 23) received 500 micrograms 2-bromo-alpha-ergocryptine (CB154) daily from 10 days of age until 4 or 5 wk of age. Serum prolactin in prepubertal male hamsters was reduced to a nondetectable level by treatment with the dopamine agonist CB154. Flank gland diameter, body weight, testicular and total accessory sex organ weights, and serum testosterone were all significantly lower (P less than 0.05) in the CB154-treated animals. In addition, seminiferous tubule area, seminiferous tubule luminal and cellular areas, and number of late spermatids per tubule cross-section were significantly reduced (P less than 0.01) in CB154-treated prepubertal males. Thus, the absence of prolactin retarded sexual maturation in male golden hamsters. These data suggest, that prolactin enhances testosterone production during the process of sexual maturation and supports the development of androgen-dependent tissues.
研究了催乳素在雄性金黄地鼠性成熟过程中的作用。对照组（n = 23）给予赋形剂，处理组（n = 23）从10日龄至4或5周龄每天接受500微克2-溴-α-麦角隐亭（CB154）。用多巴胺激动剂CB154处理使青春期前雄性仓鼠的血清催乳素降至无法检测的水平。CB154处理的动物的侧腹腺直径、体重、睾丸和附属性腺总重量以及血清睾酮均显著降低（P < 0.05）。此外，CB154处理的青春期前雄性仓鼠的生精小管面积、生精小管管腔和细胞面积以及每个小管横截面上晚期精子细胞的数量均显著减少（P < 0.01）。因此，催乳素的缺乏延缓了雄性金黄地鼠的性成熟。这些数据表明，催乳素在性成熟过程中增强睾酮的产生，并支持雄激素依赖性组织的发育。
