佩戴固定矫治器的糖尿病患者糖化血红蛋白水平与牙周细菌载量的相关性

Correlation between HbA1c Levels and Periodontal Bacterial Load in Diabetic Patients with Fixed Retainers.

作者信息

Mariș Mihaela, Bucur Sorana Maria, Mariș Marius, Păcurar Mariana, Chibelean Manuela, Nenovici Dorin, Earar Kamel

机构信息

PhD student, Doctoral School, Faculty of Medicine and Pharmacy, "Dunarea de Jos" University of Galati, Romania.

Department of Dentistry, Faculty of Medicine, "Dimitrie Cantemir" University of Târgu Mureș, Romania.

出版信息

Curr Health Sci J. 2024 Oct-Dec;50(5):570-576. doi: 10.12865/CHSJ.50.04.11. Epub 2024 Dec 31.

DOI:10.12865/CHSJ.50.04.11

PMID:40162344

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11954564/

Abstract

BACKGROUND

Fixed orthodontic retainers can promote biofilm accumulation, increasing periodontal risks in patients with type 2 diabetes. This study examines the relationship between glycated hemoglobin (HbA1c) levels and bacterial load before and after oral hygiene intervention.

METHODS

Forty diabetic patients (HbA1c: 6.5%-9%) were divided into Group I (18-30 years, n=18) and Group II (>30 years, n=22). Periodontal samples were analyzed using micro-IDent® PCR tests. Pearson's correlation and linear regression assessed associations between HbA1c and bacterial load.

RESULTS

Pre-intervention bacterial loads were 66 (Group I) and 128 (Group II). Post-intervention, they decreased significantly to 34 and 93 (p≤0.05). HbA1c showed a strong pre-intervention correlation with bacterial load (r=0.78, p=0.002), decreasing post-intervention (r=0.42, p=0.08). Each 1% HbA1c increase correlated with a 20.3-unit rise pre-intervention (R²=0.61) and 8.2 units post-intervention (R²=0.18).

CONCLUSION

Fixed retainers facilitate bacterial colonization, worsening periodontal inflammation in diabetic patients. Glycemic control and regular oral hygiene interventions are essential for reducing bacterial load and preventing complications.

摘要

背景

固定正畸保持器会促进生物膜积聚，增加2型糖尿病患者的牙周疾病风险。本研究探讨糖化血红蛋白（HbA1c）水平与口腔卫生干预前后细菌负荷之间的关系。

方法

40名糖尿病患者（HbA1c：6.5%-9%）被分为I组（18-30岁，n=18）和II组（>30岁，n=22）。使用micro-IDent® PCR检测分析牙周样本。采用Pearson相关性分析和线性回归评估HbA1c与细菌负荷之间的关联。

结果

干预前I组和II组的细菌负荷分别为66和128。干预后，细菌负荷显著降低至34和93（p≤0.05）。干预前HbA1c与细菌负荷呈强相关（r=0.78，p=0.002），干预后相关性降低（r=0.42，p=0.08）。HbA1c每升高1%，干预前细菌负荷增加20.3个单位（R²=0.61），干预后增加8.2个单位（R²=0.18）。