Novikov A M, Kozlov A M, Bassalyk L S
Biull Eksp Biol Med. 1985 Jul;100(7):76-8.
The content and profile of gangliosides (Gs) were investigated in metastatic (HMC-L) and nonmetastatic (HMC-O) mouse mammary carcinomas before and after cyclophosphamide (CP) treatment. It was shown that the Gs content did not alter markedly during HMC-O growth, whereas in HMC-L, it increased to maximum on day 15 after tumor inoculation and then dropped. CP treatment led to a steady rise in the Gs content in both tumors. The main Gs in HMC-O corresponded to GDIa, GMI, GDIb and hematosides, while in HMC-L, the main Gs at days 9-15 after tumor inoculation corresponded to GDIa (50-65% of total Gs). The action of CP on HMC-O was not accompanied by any essential alterations in the Gs profile, whereas in HMC-L on days 3-6 after CP treatment the relative content of GDIa was significantly lowered and the GMI and hematoside content markedly increased. These findings indicate that there is an obvious relation between the Gs profile and tumor ability to form metastases.
在环磷酰胺（CP）治疗前后，对转移性（HMC-L）和非转移性（HMC-O）小鼠乳腺癌中的神经节苷脂（Gs）含量及分布情况进行了研究。结果显示，在HMC-O生长过程中，Gs含量没有明显变化，而在HMC-L中，接种肿瘤后第15天Gs含量增加到最大值，随后下降。CP治疗导致两种肿瘤中Gs含量稳步上升。HMC-O中的主要Gs对应于GD1a、GM1、GD1b和血型糖苷脂，而在HMC-L中，接种肿瘤后第9 - 15天的主要Gs对应于GD1a（占总Gs的50 - 65%）。CP对HMC-O的作用并未伴随Gs分布的任何本质变化，而在CP治疗后第3 - 6天的HMC-L中，GD1a的相对含量显著降低，GM1和血型糖苷脂含量明显增加。这些发现表明，Gs分布与肿瘤形成转移的能力之间存在明显关联。
