Kliuchareva T E, Matveeva V A
Biull Eksp Biol Med. 1985 Jun;99(6):732-4.
Experiments in vivo and in vitro were made to study the effects of HETR-MLN-8 and HETR tumor cells differing in metastatic ability and inhibition of the natural host resistance to tumor on cytotoxic activity of NK from Syrian hamsters. Marked inhibition of cytotoxicity and ability for interferon activation was detected in NK isolated from tumors (as compared with blood), with that inhibition being far more pronounced in highly malignant HETR-MLN-8 tumors. This may indicate a direct inhibitory action of the tumor or its products on NK cytotoxicity. The in-vitro competition inhibition test yielded results showing that HETR-MLN-8 cells capable of in-vivo inhibition of the natural host resistance to the tumor also display much more demonstrable ability for in-vitro inhibition of NK cytotoxicity as compared to HETR cells.
进行了体内和体外实验，以研究具有不同转移能力的HETR-MLN-8和HETR肿瘤细胞以及对肿瘤天然宿主抵抗力的抑制对叙利亚仓鼠NK细胞细胞毒性活性的影响。在从肿瘤中分离出的NK细胞中检测到细胞毒性和干扰素激活能力的明显抑制（与血液相比），在高度恶性的HETR-MLN-8肿瘤中这种抑制更为明显。这可能表明肿瘤或其产物对NK细胞毒性有直接抑制作用。体外竞争抑制试验结果表明，与HETR细胞相比，能够在体内抑制肿瘤天然宿主抵抗力的HETR-MLN-8细胞在体外抑制NK细胞毒性的能力也更明显。
