Deĭchman G I, Kliuchareva T E, Kashkina L M, Matveeva V A, Teplova M A
Biull Eksp Biol Med. 1981 Nov;92(11):596-9.
Hamster embryo cells spontaneously transformed in vitro (HETr) with low metastatic activity were not capable to depress natural antitumor resistance in vivo in contrast to some other lines of Syrian hamster tumor cells. The resistance, depressing and metastatic activities of HETr parental cells and their variants obtained from lung metastases were studied and compared. The direct correlation was found between the resistance-depressing and metastatic activities of the cell variants studied. Five of eight cell variants obtained from lung metastases ocf HETr were capable to depress natural host resistance to the growth of transplanted tumor cells. They were the most active variants in the lung colonization test. It is suggested that in the course of metastasizing there takes place the selection of the tumor cell variants capable of depressing natural antitumor host resistance.
与叙利亚仓鼠肿瘤细胞的其他一些系不同，体外自发转化的具有低转移活性的仓鼠胚胎细胞（HETr）在体内不能降低天然抗肿瘤抵抗力。对HETr亲代细胞及其从肺转移灶获得的变体的抵抗力、降低抵抗力的活性和转移活性进行了研究和比较。在所研究的细胞变体的抵抗力降低活性和转移活性之间发现了直接相关性。从HETr的肺转移灶获得的八个细胞变体中有五个能够降低天然宿主对移植肿瘤细胞生长的抵抗力。它们是肺定植试验中最活跃的变体。有人提出，在转移过程中会发生能够降低天然抗肿瘤宿主抵抗力的肿瘤细胞变体的选择。
