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从担子菌毛韧革菌和颤杨生韧革菌的共培养物中分离出的振动内酯衍生物。

Vibralactone derivatives isolated from co-cultures of the basidiomycetes Stereum hirsutum and Boreostereum vibrans.

作者信息

Wei Jinjuan, Li Zhe-Xi, Peng Gao-Ke, Li Xinyang, Chen He-Ping, Liu Ji-Kai

机构信息

School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan, 430074, China.

出版信息

Nat Prod Bioprospect. 2025 Mar 31;15(1):20. doi: 10.1007/s13659-025-00505-y.

DOI:10.1007/s13659-025-00505-y
PMID:40163158
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11958929/
Abstract

The basidiomycetes Stereum hirsutum and Boreostereum vibrans are two fungi of the same genus. In this study, chemical investigation on the co-cultures of the two congeneric fungi led to the isolation of eleven new vibralactone derivatives, hirsutavibrins A-K (1-11). The structures of 1-11 were elucidated by extensive NMR and HRESIMS spectroscopic analysis, and computational methods. Hirsutavibrins A (1) and B (2) showed weak cytotoxicity against the human lung cancer cell line A549. Hirsutavibrin D (4) showed moderate anti-nitric oxide activity in murine monocytic RAW 264.7 macrophages. This work not only expands the members of vibralactone derivatives with variable configurations but also opens a new avenue for fungal co-culturing study between congeneric fungi.

摘要

担子菌纲的毛栓菌（Stereum hirsutum）和颤杨生卧孔菌（Boreostereum vibrans）是同一属的两种真菌。在本研究中，对这两种同属真菌的共培养物进行化学研究，分离得到了11种新的振动内酯衍生物，即毛栓菌振动素A - K（1 - 11）。通过广泛的核磁共振（NMR）和高分辨电喷雾电离质谱（HRESIMS）光谱分析以及计算方法确定了1 - 11的结构。毛栓菌振动素A（1）和B（2）对人肺癌细胞系A549显示出较弱的细胞毒性。毛栓菌振动素D（4）在小鼠单核巨噬细胞RAW 264.7中显示出中等程度的抗一氧化氮活性。这项工作不仅扩展了具有可变构型的振动内酯衍生物的成员，也为同属真菌之间的共培养研究开辟了一条新途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf9a/11958929/617a2f7ac85c/13659_2025_505_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf9a/11958929/e3e73cd342fb/13659_2025_505_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf9a/11958929/d701f799f241/13659_2025_505_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf9a/11958929/431de46f1b90/13659_2025_505_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf9a/11958929/617a2f7ac85c/13659_2025_505_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf9a/11958929/e3e73cd342fb/13659_2025_505_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf9a/11958929/4e7b6fa6e723/13659_2025_505_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf9a/11958929/d701f799f241/13659_2025_505_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf9a/11958929/431de46f1b90/13659_2025_505_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bf9a/11958929/617a2f7ac85c/13659_2025_505_Fig5_HTML.jpg

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