来自担子菌振动韧革菌的具有振动内酯骨架的新型天然肟类和肟酯类化合物。
Novel Natural Oximes and Oxime Esters with a Vibralactone Backbone from the Basidiomycete Boreostereum vibrans.
作者信息
Chen He-Ping, Zhao Zhen-Zhu, Li Zheng-Hui, Dong Ze-Jun, Wei Kun, Bai Xue, Zhang Ling, Wen Chun-Nan, Feng Tao, Liu Ji-Kai
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany Chinese Academy of Sciences Kunming 650201 P. R. China; University of Chinese Academy of Sciences Beijing 100049 P.R. China.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany Chinese Academy of Sciences Kunming 650201 P. R. China; School of Pharmaceutical Sciences South-Central University for Nationalities Wuhan 430074 P. R. China.
出版信息
ChemistryOpen. 2016 Jan 13;5(2):142-9. doi: 10.1002/open.201500198. eCollection 2016 Apr.
A variety of novel natural products with significant bioactivities are produced by the basidiomycete Boreostereum vibrans. In the present study, we describe 16 novel natural oximes and oxime esters with a vibralactone backbone, vibralactoximes, which were isolated from the scale-up fermentation broth of B. vibrans. Their structures were determined through extensive spectroscopic analyses. These compounds represent the first oxime esters from nature. The hypothetical biosynthetic pathway of these compounds was also proposed. Seven compounds exhibited significant pancreatic lipase inhibitory activity, while ten compounds exhibited cytotoxicities against five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW480), with IC50 values comparable with those of cisplatin.
担子菌Boreostereum vibrans能产生多种具有显著生物活性的新型天然产物。在本研究中，我们描述了16种具有振动内酯骨架的新型天然肟和肟酯，即振动内酯肟，它们是从B. vibrans的放大发酵液中分离得到的。通过广泛的光谱分析确定了它们的结构。这些化合物代表了自然界中首次发现的肟酯。还提出了这些化合物的假定生物合成途径。七种化合物表现出显著的胰脂肪酶抑制活性，而十种化合物对五种人类癌细胞系（HL-60、SMMC-7721、A-549、MCF-7和SW480）具有细胞毒性，其IC50值与顺铂相当。
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