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小儿巨大胶质错构瘤的手术治疗:一例报告

Surgical management of a giant glial hamartoma in a pediatric patient: a case report.

作者信息

Sharifi Guive, Paraandavaji Elham, Naghizadeh Shahin, Nilipour Yalda, Kazemi Mohammad Ali, Khanbabazadeh Sajjad, Taghizadeh-Hesary Farzad

机构信息

Department of Neurosurgery, Loghman Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

Childs Nerv Syst. 2025 Mar 31;41(1):145. doi: 10.1007/s00381-025-06792-7.

Abstract

INTRODUCTION

Glial hamartomas are benign growths of glial cells, and their management is challenging due to their rarity and variable presentation. We present a case of a giant glial hamartoma in a pediatric patient, incidentally discovered during routine imaging for a planned tonsillectomy.

CASE DESCRIPTION

A 7-year-old boy with no prior neurological symptoms was found to have a large glial hamartoma in the right frontal lobe, measuring 67 mm in height and 50 mm in transverse diameter. Imaging studies revealed a hyperdense mass with internal calcifications on CT, hypointense on T1-weighted MRI, and hyperintense on T2-weighted MRI. Histopathology confirmed the diagnosis, showing benign glial cells, Rosenthal fibers, and eosinophilic granular bodies. A multidisciplinary team decided on surgical resection due to the tumor's size. The tumor was resected without complications, and postoperative recovery was uneventful. Follow-up MRIs at 4 months and 2 years post-surgery showed no residual tumor or recurrence.

CONCLUSIONS

This case underscores the role of radiological evaluation in identifying rare asymptomatic glial hamartomas and supports surgical resection to prevent complications. Comprehensive follow-up is essential for early detection of any recurrence.

摘要

引言

胶质错构瘤是胶质细胞的良性增生,因其罕见性和表现各异,对其治疗颇具挑战性。我们报告一例儿科患者的巨大胶质错构瘤,该瘤在计划扁桃体切除术前的常规影像学检查中偶然发现。

病例描述

一名既往无神经症状的7岁男孩,被发现右侧额叶有一个巨大的胶质错构瘤,高度为67毫米,横径为50毫米。影像学检查显示,CT上为高密度肿块伴内部钙化,T1加权磁共振成像(MRI)上为低信号,T2加权MRI上为高信号。组织病理学确诊,显示为良性胶质细胞、罗森塔尔纤维和嗜酸性颗粒小体。由于肿瘤体积较大,多学科团队决定进行手术切除。肿瘤被顺利切除,术后恢复平稳。术后4个月和2年的随访MRI显示无残留肿瘤或复发。

结论

该病例强调了放射学评估在识别罕见无症状胶质错构瘤中的作用,并支持手术切除以预防并发症。全面的随访对于早期发现任何复发至关重要。

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