一项基于网络的个性化干预措施对提高艾滋病毒/艾滋病感染者人乳头瘤病毒疫苗接种率的随机对照试验。
A randomized, controlled trial of a web-based tailored intervention to increase human papillomavirus vaccination among people living with HIV/AIDS.
作者信息
de Brito Kaliane Caldas, da Silva Miralba Freire de Carvalho Ribeiro, Cardoso Cristiane Wanderley, Silva Luciano Kalabric, Khouri Ricardo, de Albuquerque Junior Antônio Eduardo, Vianna Nelzair Araújo, Almeida Maria da Conceição Chagas de, Moreira Junior Edson Duarte
机构信息
Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Brazilian Ministry of Health, Salvador, Bahia, Brazil.
Assistência e Pesquisa, Centro Estadual Especializado em Diagnóstico, Salvador, Bahia, Brazil.
出版信息
PLoS One. 2025 Mar 31;20(3):e0319646. doi: 10.1371/journal.pone.0319646. eCollection 2025.
BACKGROUND
Human papillomavirus (HPV) causes several cancers that disproportionally affect people living with HIV/AIDS (PLWH) yet there is a paucity of research on interventions to foster HPV vaccine use in this population. We sought to evaluate the efficacy of a web-based, tailored intervention (e-HPV) to promote HPV vaccination among PLWH.
METHODS
This is a randomized controlled trial with PLWH aged 18 to 45 years. Participants were recruited between January and June 2022 and randomized into two groups: experimental group (e-HPV), which received information about HPV and the HPV vaccine, based on the Protection Motivation Theory and control group, who received a clipping of information from the page maintained by the Ministry of Health dedicated to informing the population about HPV and the HPV vaccine. The primary and secondary outcomes were the percentage of PLWH willing to get HPV vaccine and HPV vaccine initiation (i.e., receipt of any doses by PLWH), respectively.
RESULTS
A total of 654 individuals were randomly allocated: 327 in the e-HPV and 327 in the control group. The average age was 29.7 years, the majority were men (71.4%), black or mixed race (63.2%). The intention to get vaccinated against HPV was approximately twice as high among participants in the e-HPV vs. control group (OR = 2.0, 95% CI: 1.3-3.4; p < 0.003), and HPV vaccine initiation was also significantly more common among participants in the e-HPV group (OR = 2.1, 95% CI: 1.1-4.0; p = 0.03). Belief in the effectiveness of the HPV vaccine, risk perception and the severity of an HPV infection were the reasons most reported by participants intending to get HPV vaccination.
CONCLUSIONS
The intervention was acceptable and efficacious in increasing HPV vaccination among PLWH. Future studies are warranted to optimize and disseminate the e-HPV intervention to settings providing services to PLWH.
TRIAL REGISTRATION
Brazilian Clinical Trials Registry RBR-557mbvy.
背景
人乳头瘤病毒（HPV）引发多种癌症，对艾滋病毒/艾滋病感染者（PLWH）的影响尤为严重，但针对促进该人群使用HPV疫苗的干预措施的研究却很匮乏。我们旨在评估一种基于网络的个性化干预措施（e-HPV）在促进PLWH接种HPV疫苗方面的效果。
方法
这是一项针对18至45岁PLWH的随机对照试验。参与者于2022年1月至6月招募，并随机分为两组：实验组（e-HPV），根据保护动机理论接收有关HPV和HPV疫苗的信息；对照组，接收卫生部维护的页面上关于向公众宣传HPV和HPV疫苗的信息片段。主要和次要结果分别是愿意接种HPV疫苗的PLWH的百分比和HPV疫苗接种开始情况（即PLWH接种任何剂量疫苗）。
结果
共随机分配了654人：e-HPV组327人，对照组327人。平均年龄为29.7岁，大多数为男性（71.4%），黑人或混血（63.2%）。e-HPV组参与者接种HPV疫苗的意愿约为对照组的两倍（OR = 2.0，95% CI：1.3 - 3.4；p < 0.003），e-HPV组参与者中HPV疫苗接种开始情况也明显更常见（OR = 2.1，95% CI：1.1 - 4.0；p = 0.03）。认为HPV疫苗有效、风险认知以及HPV感染的严重性是打算接种HPV疫苗的参与者最常提及的原因。
结论
该干预措施在增加PLWH的HPV疫苗接种方面是可接受且有效的。未来有必要进行研究，以优化并将e-HPV干预措施推广到为PLWH提供服务的场所。
试验注册
巴西临床试验注册中心RBR - 557mbvy
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