Karagiannidis Artemios G, Theodorakopoulou Marieta P, Iatridi Fotini, Ortiz Alberto, Sarafidis Pantelis
First Department of Nephrology, Hippokration Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Department of Nephrology and Hypertension, IIS-Fundacion Jimenez Diaz UAM, Madrid, Spain.
J Hum Hypertens. 2025 May;39(5):320-333. doi: 10.1038/s41371-025-01013-9. Epub 2025 Mar 31.
Uromodulin is a kidney-specific glycoprotein which is uniquely synthesized by the epithelial cells lining the thick ascending limb and early distal convoluted tubule. Among multiple roles in complex physiological and pathological processes, uromodulin mediates renal sodium handling through modulating tubular sodium transporters that reabsorb sodium and therefore is putatively linked to hypertension through generating sodium sensitivity of blood pressure. This review aims to present an updated overview of the role of uromodulin in sodium renal handling and summarize the existing evidence originating from preclinical, genetic, and clinical studies that support a relationship between uromodulin and sodium-sensitive hypertension.
尿调节蛋白是一种肾脏特异性糖蛋白，由髓袢升支粗段和远端小管起始段的上皮细胞独特合成。在复杂的生理和病理过程中，尿调节蛋白发挥多种作用，它通过调节重吸收钠的肾小管钠转运体来介导肾脏对钠的处理，因此可能通过产生血压的钠敏感性而与高血压相关。本综述旨在提供尿调节蛋白在肾脏钠处理中作用的最新概述，并总结来自临床前、遗传学和临床研究的现有证据，这些证据支持尿调节蛋白与钠敏感性高血压之间的关系。
