Shao Xiangzhi, Xie Zuopu, Zhu Lielie
Department of Rehabilitation, Wenzhou TCM Hospital of Zhejiang Chinese Medical University, No. 9 Jiaowei Road, Lucheng District, Wenzhou city, Zhejiang, P. R. China.
Department of Gastroenterology, Pingyang Hospital of Wenzhou Medical University, Pingyang county, Wenzhou city, Zhejiang Province, China.
BMC Psychiatry. 2025 Mar 31;25(1):306. doi: 10.1186/s12888-025-06730-6.
Depression is intricately correlated with systemic inflammatory responses. The Inflammatory Burden Index (IBI) has recently been introduced as a comprehensive metric for evaluating systemic inflammation. This study aims to explore the correlation between IBI and depression in the general population.
This cross-sectional study was designed to analyze the data from National Health and Nutrition Examination Survey (NHANES) during the period from 1999 to 2018. IBI was formulated as C-reactive protein×neutrophils/lymphocytes. The correlation between the prevalence of depression and IBI was explored through multivariate logistic regression analyses, as well as subgroup, interaction, restricted cubic spline (RCS) and sensitivity analyses.
A total of 14,557 subjects were included in this study, of whom, 1231 (8.5%) had depression. According to multivariate logistic regression and RCS analyses, a significantly linearly positive correlation was observed between IBI and depression [odds ratio (OR) = 1.03, 95% confidence intervals (CI): 1.01, 1.05, P = 0.007]. Subjects in the third tertile of IBI exhibited a significantly higher prevalence of depression, with 40.0% affected, compared to those in the first tertile (P < 0.001). This correlation was consistently observed across all subgroups through stratified analysis (all interaction P > 0.05). After sensitivity analyses excluding participants with upper and lower 2.5% of IBI, the correlation between IBI and depression remained stable (OR = 1.08; 95%CI, 1.01, 1.15, P < 0.001).
These findings in this study indicate a positive correlation between IBI and depression in American adults. Further large-scale prospective studies are still needed to analyze the role of IBI in depression.
抑郁症与全身炎症反应密切相关。炎症负担指数（IBI）最近被引入作为评估全身炎症的综合指标。本研究旨在探讨普通人群中IBI与抑郁症之间的相关性。
本横断面研究旨在分析1999年至2018年期间美国国家健康与营养检查调查（NHANES）的数据。IBI的计算公式为C反应蛋白×中性粒细胞/淋巴细胞。通过多变量逻辑回归分析以及亚组、交互作用、限制立方样条（RCS）和敏感性分析，探讨抑郁症患病率与IBI之间的相关性。
本研究共纳入14557名受试者，其中1231名（8.5%）患有抑郁症。根据多变量逻辑回归和RCS分析，观察到IBI与抑郁症之间存在显著的线性正相关[优势比（OR）=1.03，95%置信区间（CI）：1.01，1.05，P=0.007]。与第一三分位数的受试者相比，IBI第三三分位数的受试者抑郁症患病率显著更高，为40.0%（P<0.001）。通过分层分析在所有亚组中均一致观察到这种相关性（所有交互作用P>0.05）。在排除IBI上下2.5%的参与者进行敏感性分析后，IBI与抑郁症之间的相关性仍然稳定（OR=1.08；95%CI，1.01，1.15，P<0.001）。
本研究的这些结果表明，美国成年人中IBI与抑郁症之间存在正相关。仍需要进一步的大规模前瞻性研究来分析IBI在抑郁症中的作用。
