Basu Syamantak, Ulbricht Ying, Rossol Manuela
Molecular Immunology, Faculty of Health Sciences, Brandenburg University of Technology (BTU) Cottbus-Senftenberg, Senftenberg, Germany.
Faculty of Environment and Natural Sciences, Brandenburg University of Technology (BTU) Cottbus-Senftenberg, Senftenberg, Germany.
Front Immunol. 2025 Mar 17;16:1506165. doi: 10.3389/fimmu.2025.1506165. eCollection 2025.
Aging is associated with immunosenescence, a decline in immune functions, but also with inflammaging, a chronic, low-grade inflammation, contributing to immunosenescence. Monocytes and macrophages belong to the innate immune system and aging has a profound impact on these cells, leading to functional changes and most importantly, to the secretion of pro-inflammatory cytokines and thereby contributing to inflammaging. Rheumatoid arthritis (RA) is an autoimmune disease and age is an important risk factor for developing RA. RA is associated with the early development of age-related co-morbidities like cardiovascular manifestations and osteoporosis. The immune system of RA patients shows signs of premature aging like age-inappropriate increased production of myeloid cells, accelerated telomeric erosion, and the uncontrolled production of pro-inflammatory cytokines. In this review we discuss the influence of aging on monocytes and macrophages during healthy aging and premature aging in rheumatoid arthritis.
衰老与免疫衰老相关，即免疫功能衰退，但也与炎症衰老相关，炎症衰老是一种慢性低度炎症，会导致免疫衰老。单核细胞和巨噬细胞属于先天性免疫系统，衰老对这些细胞有深远影响，导致功能变化，最重要的是，导致促炎细胞因子的分泌，从而促进炎症衰老。类风湿性关节炎（RA）是一种自身免疫性疾病，年龄是患RA的重要风险因素。RA与心血管疾病和骨质疏松症等与年龄相关的合并症的早期发生有关。RA患者的免疫系统表现出过早衰老的迹象，如骨髓细胞产生异常增加、端粒加速侵蚀以及促炎细胞因子的失控产生。在这篇综述中，我们讨论了在健康衰老和类风湿关节炎过早衰老过程中，衰老对单核细胞和巨噬细胞的影响。
