Brister S, Fradet G, Dewar M, Wittnich C, Lough J, Chiu R C
Can J Surg. 1985 Jul;28(4):341-4.
Canine experiments were undertaken to determine the feasibility of transforming skeletal muscle for myocardial assistance. Initially, a rectus-muscle pedicle flap was used to power a ventricular assist conduit. A specially designed "pulse-train" stimulator produced skeletal muscle contractions capable of augmenting myocardial function. Statistically significant increases in either systolic or diastolic pressures were achieved by appropriate synchronization and signal delays of the stimulator. Then, the left rectus muscle was conditioned by stimulating it at low frequencies (2 to 10 Hz) for 6 to 12 weeks. The degree of transformation from type II (fast) to type I (slow) fibres was examined and the resultant tolerance to fatigue studied. Preliminary data show that a greater proportion of type I fibres is associated with increased resistance to fatigue. Such transformed skeletal muscle should therefore be more suited to power the cardiac assist devices.
进行犬类实验以确定将骨骼肌转化用于心肌辅助的可行性。最初，使用腹直肌蒂瓣为心室辅助导管提供动力。一种专门设计的“脉冲序列”刺激器可产生能够增强心肌功能的骨骼肌收缩。通过刺激器的适当同步和信号延迟，收缩压或舒张压实现了具有统计学意义的升高。然后，通过以低频（2至10赫兹）刺激左腹直肌6至12周对其进行预处理。检测了从II型（快）纤维向I型（慢）纤维的转化程度，并研究了由此产生的疲劳耐受性。初步数据表明，I型纤维比例更高与抗疲劳能力增强相关。因此，这种转化后的骨骼肌应该更适合为心脏辅助装置提供动力。
