Tassavor Bryan, Young Eun Chae, Nikolskaia Olga, Jobarteh-Williams Ruth
Medical School, A.T. Still University School of Osteopathic Medicine in Arizona, Mesa, USA.
Medical School, Drexel University, Philadelphia, USA.
Cureus. 2025 Feb 27;17(2):e79804. doi: 10.7759/cureus.79804. eCollection 2025 Feb.
Kratom, an opioid substitute derived from the leaves of , is commonly used for its opioid-like effects in East Asia and is gaining popularity in the United States. A rare side effect of chronic kratom use, previously noted in the literature, is skin hyperpigmentation. We present a unique case of diffuse, photodistributed hyperpigmentation in a patient with over a decade of kratom use. This case is accompanied by an evaluation of the adverse effect, focusing on its clinical presentation, histopathological findings, and potential mechanism. Additionally, we provide a brief literature review on the topic.
kratom是一种从[植物名称]叶子中提取的阿片类替代品，在东亚因其类阿片作用而被广泛使用，且在美国正日益流行。文献中先前已指出，长期使用kratom的一种罕见副作用是皮肤色素沉着。我们报告了一例有十多年kratom使用史的患者出现弥漫性、光分布性色素沉着的独特病例。本病例还伴有对该不良反应的评估，重点关注其临床表现、组织病理学发现及潜在机制。此外，我们还提供了关于该主题的简要文献综述。
