Mowé G, Gylseth B, Hartveit F, Skaug V
Cancer. 1985 Sep 1;56(5):1089-93. doi: 10.1002/1097-0142(19850901)56:5<1089::aid-cncr2820560522>3.0.co;2-y.
The risk of malignant mesothelioma associated with low-level asbestos exposure is an important unresolved issue today. We have analyzed the asbestos fiber concentration in lung tissue from 14 cases of malignant mesothelioma and 28 case-matched controls by scanning electron microscopy. The cases represent 86% of all mesotheliomas recorded by the Cancer Registry of Norway from the county of Hordaland between 1970 and 1979. Based on 1 million fibers per g of dried tissue as an indicator of cumulated asbestos exposure, the odds ratio (relative risk) was 8.5 (95% confidence limits, 2.3-31.1). Assuming that the risk of malignant mesothelioma is related to mineral fiber concentration in lung tissue, it is concluded that a fiber concentration exceeding 1 million fibers per g of dried tissue is associated with an increased risk of malignant mesothelioma. Furthermore, the results are consistent with a no-threshold response.
与低水平石棉暴露相关的恶性间皮瘤风险是当今一个重要的未解决问题。我们通过扫描电子显微镜分析了14例恶性间皮瘤患者及28例病例匹配对照的肺组织中的石棉纤维浓度。这些病例占挪威霍达兰郡癌症登记处1970年至1979年记录的所有间皮瘤病例的86%。以每克干燥组织中100万根纤维作为累积石棉暴露的指标，优势比（相对风险）为8.5（95%置信区间，2.3 - 31.1）。假设恶性间皮瘤风险与肺组织中的矿物纤维浓度相关，得出结论：每克干燥组织中纤维浓度超过100万根与恶性间皮瘤风险增加相关。此外，结果与无阈值反应一致。
