Mowé G, Gylseth B
Am J Ind Med. 1986;9(4):323-32. doi: 10.1002/ajim.4700090403.
This investigation is based on a study of 117 men and 24 women with malignant mesothelioma registered by the Cancer Registry of Norway, 1970-79. The age-adjusted incidence rate in men for each county varied from 1.7 to 13.3 per million per year. Eighty-two percent of the men revealed possible occupational asbestos exposure. They were evenly distributed between counties with high and low mesothelioma incidence. Only 17% of the women had possible occupational asbestos exposure. Total lung fiber concentration was analyzed with scanning electron microscopy in 65 men and 13 women. The median lung fiber concentration in men was 2.4 million per gram of dried tissue (range less than 0.4-490), in women 1.0 million per gram (range less than 0.4-41), and in male controls less than 0.4 million per gram (range less than 0.4-4.8). The median year of first exposure was 1937 (range 1909-60) for men from counties with a high incidence rate and 1945 (range 1938-59) for men from counties with a low incidence rate. The counties with a high compared to a low incidence rate of malignant mesothelioma, 1970-79, showed an apparent difference in the percentage of population employed in industry in 1946. The regional variation in the incidence of malignant mesothelioma in men is mainly attributable to the proportion of population exposed to asbestos in industry per county prior the 1950s and the time since exposure started.(ABSTRACT TRUNCATED AT 250 WORDS)
这项调查基于对1970 - 1979年挪威癌症登记处登记的117名男性和24名女性恶性间皮瘤患者的研究。各县男性的年龄调整发病率为每年每百万人1.7至13.3例。82%的男性显示可能有职业性石棉接触史。他们在间皮瘤发病率高和低的县之间分布均匀。只有17%的女性有职业性石棉接触的可能。对65名男性和13名女性的肺纤维总浓度进行了扫描电子显微镜分析。男性肺纤维浓度中位数为每克干组织240万根（范围小于0.4至490），女性为每克100万根（范围小于0.4至41），男性对照组小于每克40万根（范围小于0.4至4.8）。高发病率县男性首次接触的中位数年份为1937年（范围1909 - 1960），低发病率县男性为1945年（范围1938 - 1959）。1970 - 1979年恶性间皮瘤发病率高的县与低的县相比，1946年从事工业的人口百分比存在明显差异。男性恶性间皮瘤发病率的区域差异主要归因于20世纪50年代之前各县工业中接触石棉的人口比例以及接触开始后的时间。（摘要截断于250字）
