Wick M R, Goellner J R, Wolfe J T, Su W P
Cancer. 1985 Sep 1;56(5):1163-72. doi: 10.1002/1097-0142(19850901)56:5<1163::aid-cncr2820560533>3.0.co;2-a.
Extraocular sebaceous carcinomas are uncommonly seen neoplasms, and have been confused in the past with basal cell carcinomas showing sebaceous differentiation. In contrast to the latter tumors, however, sebaceous carcinomas have a distinct risk of aggressive behavior. This study presents clinicopathologic data on five cases of sebaceous carcinoma arising in cutaneous locations outside of the ocular adnexae. Four of five patients were men, and the average age at diagnosis was 63 years. Three tumors occurred on the face, one arose in the skin of the neck, and another occurred on the penis, an anatomic site that is extremely rare for sebaceous carcinoma. Three tumors metastasized, and two patients died of tumor or with residual tumor growth. In light of this behavior, the premise that extraocular sebaceous carcinomas rarely spread to distant sites may need reexamination.
眼外皮脂腺癌是一种罕见的肿瘤，过去曾与表现为皮脂腺分化的基底细胞癌相混淆。然而，与后一种肿瘤不同的是，皮脂腺癌具有明显的侵袭性行为风险。本研究报告了5例发生于眼附属器以外皮肤部位的皮脂腺癌的临床病理资料。5例患者中有4例为男性，诊断时的平均年龄为63岁。3例肿瘤发生在面部，1例发生在颈部皮肤，另1例发生在阴茎，这是皮脂腺癌极为罕见的解剖部位。3例肿瘤发生转移，2例患者死于肿瘤或有残留肿瘤生长。鉴于这种情况，眼外皮脂腺癌很少转移至远处部位这一前提可能需要重新审视。
