Yamamoto Yuta, Nakamura Toshitsugu, Koyama Hiroshi, Kanai Toshiharu, Moritani Suzuko, Ichihara Shu
Department of Surgery, Suwa Red Cross Hospital, Suwa, Japan.
Present address: Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
Surg Case Rep. 2017 Dec;3(1):38. doi: 10.1186/s40792-017-0312-4. Epub 2017 Feb 23.
Sebaceous carcinoma of the breast is a distinct variant of invasive ductal carcinoma. It is rare and only several cases have been reported.
An 80-year-old woman noted bloody discharge from her left nipple and palpated a lump in her left breast. Ultrasonography revealed a 19-mm mass in the left breast. Fine-needle aspiration suggested invasive ductal carcinoma. Partial mastectomy and sentinel lymph node biopsy were performed. On histological examination, the tumor revealed solid growth of small, round uniform cells with clear cytoplasm, partially intermingled with vacuolated cells indicative of sebaceous differentiation. The tumor cells contained abundant Sudan Black B-positive lipid droplets in the cytoplasm, and they were immunohistochemically positive for adipophilin. They were negative for estrogen receptor, progesterone receptor, and androgen receptor; positive for cytokeratin 7 and Ber-EP4; and partially positive for epithelial membrane antigen. Based on these findings, the patient was diagnosed with sebaceous carcinoma of the breast.
We diagnosed a rare case of sebaceous carcinoma of the breast.
乳腺皮脂腺癌是浸润性导管癌的一种独特变异型。它很罕见，仅有数例病例被报道。
一名80岁女性注意到左侧乳头有血性溢液，并摸到左乳有一个肿块。超声检查显示左乳有一个19毫米的肿物。细针穿刺提示为浸润性导管癌。遂行保乳手术及前哨淋巴结活检。组织学检查显示，肿瘤由小的、圆形的、胞质清亮的均匀细胞呈实性生长，部分与提示皮脂腺分化的空泡状细胞混合。肿瘤细胞胞质内含有丰富的苏丹黑B阳性脂滴，免疫组化显示脂联素呈阳性。雌激素受体、孕激素受体及雄激素受体均为阴性；细胞角蛋白7和Ber-EP4呈阳性；上皮膜抗原部分呈阳性。基于这些发现，该患者被诊断为乳腺皮脂腺癌。
我们诊断了一例罕见的乳腺皮脂腺癌病例。
